The timing and progression of DNA methylation changes during carcinogenesis are not
completely understood. To develop a timeline of aberrant DNA methylation events during …

Tumourigenic transformation of normal cells into cancer typically involves several steps
resulting in acquisition of unlimited growth potential, evasion of apoptosis and non …

Malignant cancer emerges from normal healthy cells in a multistep process that involves
both genetic and epigenetic lesions. Both genetic and environmental inputs participate in …

Background Dysregulation of the epigenome is a common event in malignancy; however,
deciphering the earliest cancer-associated epigenetic events remains a challenge. Cancer …

Background Breast cancer formation is associated with frequent changes in DNA
methylation but the extent of very early alterations in DNA methylation and the biological …

Background Cancer cells undergo massive alterations to their DNA methylation patterns that
result in aberrant gene expression and malignant phenotypes. However, the mechanisms …

Background The underlying biological mechanisms through which epidemiologically
defined breast cancer risk factors contribute to disease risk remain poorly understood …

Breast cancer is the most common malignancy among women worldwide. Risk assessment
is one of the main services delivered by cancer clinics. Biomarker analysis on different …

Breast cancer, one of the most common and deadliest malignancies in developed countries,
is a remarkably heterogeneous disease, which is clinically reflected by patients who display …

Breast cancers exhibit genome-wide aberrant DNA methylation patterns. To investigate how
these affect the transcriptome and which changes are linked to transformation or …