Ubiquitination of retinoblastoma family protein 1 potentiates gene-specific repression function
The retinoblastoma (RB) tumor suppressor family functions as a regulatory node governing
cell cycle progression, differentiation, and apoptosis. Post-translational modifications play a …
cell cycle progression, differentiation, and apoptosis. Post-translational modifications play a …
Role of Drosophila retinoblastoma protein instability element in cell growth and proliferation
JS Elenbaas, R Mouawad, RW Henry, DN Arnosti… - Cell cycle, 2015 - Taylor & Francis
The RB tumor suppressor, a regulator of the cell cycle, apoptosis, senescence, and
differentiation, is frequently mutated in human cancers. We recently described an …
differentiation, is frequently mutated in human cancers. We recently described an …
Paradoxical instability–activity relationship defines a novel regulatory pathway for retinoblastoma proteins
The Retinoblastoma (RB) transcriptional corepressor and related family of pocket proteins
play central roles in cell cycle control and development, and the regulatory networks …
play central roles in cell cycle control and development, and the regulatory networks …
Integrated stability and activity control of the Drosophila Rbf1 retinoblastoma protein
The retinoblastoma (RB) family transcriptional corepressors regulate diverse cellular events
including cell cycle, senescence, and differentiation. The activity and stability of these …
including cell cycle, senescence, and differentiation. The activity and stability of these …
The evolutionarily conserved C-terminal domains in the mammalian retinoblastoma tumor suppressor family serve as dual regulators of protein stability and …
S Sengupta, R Lingnurkar, TS Carey… - Journal of Biological …, 2015 - ASBMB
The retinoblastoma (RB) tumor suppressor and related family of proteins play critical roles in
development through their regulation of genes involved in cell fate. Multiple regulatory …
development through their regulation of genes involved in cell fate. Multiple regulatory …
Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function
MP Markey, J Bergseid, EE Bosco, K Stengel, H Xu… - Oncogene, 2007 - nature.com
Functional inactivation of the retinoblastoma tumor suppressor gene product (RB) is a
common event in human cancers. Classically, RB functions to constrain cellular proliferation …
common event in human cancers. Classically, RB functions to constrain cellular proliferation …
Distinct developmental expression of Drosophila retinoblastoma factors
SA Keller, Z Ullah, MS Buckley, RW Henry… - Gene expression …, 2005 - Elsevier
Retinoblastoma (RB) tumor suppressor proteins are important regulators of the cell cycle
and are implicated in a wide variety of human tumors. Genetic analysis of RB mutations in …
and are implicated in a wide variety of human tumors. Genetic analysis of RB mutations in …
Diversification of retinoblastoma protein function associated with cis and trans adaptations
Retinoblastoma proteins are eukaryotic transcriptional corepressors that play central roles in
cell cycle control, among other functions. Although most metazoan genomes encode a …
cell cycle control, among other functions. Although most metazoan genomes encode a …
RB localizes to DNA double-strand breaks and promotes DNA end resection and homologous recombination through the recruitment of BRG1
R Vélez-Cruz, S Manickavinayaham… - Genes & …, 2016 - genesdev.cshlp.org
The retinoblastoma (RB) tumor suppressor is recognized as a master regulator that controls
entry into the S phase of the cell cycle. Its loss leads to uncontrolled cell proliferation and is a …
entry into the S phase of the cell cycle. Its loss leads to uncontrolled cell proliferation and is a …
A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis
NS Moon, L Di Stefano, N Dyson - Molecular and cellular biology, 2006 - Am Soc Microbiol
The inactivation of retinoblastoma (Rb) family members sensitizes cells to apoptosis. This
cell death affects the development of mutant animals and also provides a critical constraint …
cell death affects the development of mutant animals and also provides a critical constraint …