[HTML][HTML] Significance of cancer stroma for bone destruction in oral squamous cell carcinoma using different cancer stroma subtypes

Q Shan, K Takabatake, H Kawai… - Oncology …, 2022 - spandidos-publications.com
Stromal cells in the tumor microenvironment (TME) can regulate the progression of
numerous types of cancer; however, the bone invasion of oral squamous cell carcinoma …

Investigation of bone invasion and underlying mechanisms of oral cancer using a cell line‑derived xenograft model

Q Shan, K Takabatake, H Omori… - Oncology …, 2022 - spandidos-publications.com
The cancer stroma regulates bone invasion in oral squamous cell carcinoma (OSCC).
However, data on normal stroma are limited. In the present study, the effects of gingival and …

The origin of stroma influences the biological characteristics of oral squamous cell carcinoma

H Omori, Q Shan, K Takabatake, K Nakano, H Kawai… - Cancers, 2021 - mdpi.com
Simple Summary Normal stromal cells play a significant role in the progression of cancers
but are poorly investigated in oral squamous cell carcinoma (OSCC). In this study, we found …

Stromal cells in the tumor microenvironment promote the progression of oral squamous cell carcinoma

Q Shan, K Takabatake, H Omori… - International …, 2021 - spandidos-publications.com
The stromal cells in the tumor microenvironment (TME) can influence the progression of
multiple types of cancer; however, data on oral squamous cell carcinoma (OSCC) are …

Cancer-associated stromal cells promote the contribution of mmp2-positive bone marrow-derived cells to oral squamous cell carcinoma invasion

MW Oo, H Kawai, K Takabatake, Q Shan, HS Eain… - Cancers, 2021 - mdpi.com
Simple Summary Based on its invasiveness, oral squamous cell carcinoma (OSCC) shows
two different subtypes: less-invasive verrucous squamous carcinoma (VSCC) or highly …

Crosstalk between cancer and different cancer stroma subtypes promotes the infiltration of tumor‑associated macrophages into the tumor microenvironment of oral …

Q Shan, K Takabatake, H Kawai… - International …, 2022 - spandidos-publications.com
Tumor‑associated macrophages (TAMs) are linked to the progression of numerous types of
cancer. However, the effects of the tumor microenvironment (TME) of oral squamous cell …

Human bone marrow mesenchymal stem cells induce collagen production and tongue cancer invasion

S Salo, C Bitu, K Merkku, P Nyberg, IO Bello… - PLoS …, 2013 - journals.plos.org
Tumor microenvironment (TME) is an active player in carcinogenesis and changes in its
composition modify cancer growth. Carcinoma-associated fibroblasts, bone marrow-derived …

Interactions of human MSC with head and neck squamous cell carcinoma cell line PCI-13 reduce markers of epithelia-mesenchymal transition

F Böhrnsen, M Fricke, C Sander, A Leha… - Clinical Oral …, 2015 - Springer
Objectives Cancer progression is influenced by tumor microenvironment and
communication of stromal cells and tumor cells. Interactions may enhance epithelial …

Transforming growth factor-β1 treatment of oral cancer induces epithelial-mesenchymal transition and promotes bone invasion via enhanced activity of osteoclasts

J Quan, M Elhousiny, NW Johnson, J Gao - Clinical & experimental …, 2013 - Springer
This study investigates relationships between EMT and bone invasion by OSCC. Three
OSCC cell lines, SCC25, HN5, and Tca8113 were artificially induced to display EMT by …

BMSC–HNC Interaction: Exploring Effects on Bone Integrity and Head and Neck Cancer Progression

J Eichberger, D Froschhammer, D Schulz… - International Journal of …, 2023 - mdpi.com
In recent research, the tumor microenvironment has been shown to attract mesenchymal
stromal cells (MSCs), which is of particular interest due to its implications for cancer …