Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane
BR Kim, R Hu, YS Keum, V Hebbar, G Shen, SS Nair… - Cancer research, 2003 - AACR
Sulforaphane (SFN) and its N-acetyl-l-cysteine (NAC) conjugate are effective inhibitors of
tumorigenesis in animal models. These compounds induce the expression of the antioxidant …
tumorigenesis in animal models. These compounds induce the expression of the antioxidant …
Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces phase 2 drug-metabolizing enzymes
C Gerhäuser, M You, J Liu, RM Moriarty, M Hawthorne… - Cancer Research, 1997 - AACR
Chemoprevention involves the use of natural or synthetic substances to reduce the risk of
developing cancer. Two dietary components capable of mediating chemopreventive activity …
developing cancer. Two dietary components capable of mediating chemopreventive activity …
Antioxidant effects of sulforaphane in human HepG2 cells and immortalised hepatocytes
Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its
effectiveness has been limited in human studies. Here, the effects of SFN were measured in …
effectiveness has been limited in human studies. Here, the effects of SFN were measured in …
Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species
SV Singh, SK Srivastava, S Choi, KL Lew… - Journal of Biological …, 2005 - ASBMB
We have shown previously that sulforaphane (SFN), a constituent of many edible cruciferous
vegetables including broccoli, suppresses growth of prostate cancer cells in culture as well …
vegetables including broccoli, suppresses growth of prostate cancer cells in culture as well …
Biphasic modulation of cell proliferation by sulforaphane at physiologically relevant exposure times in a human colon cancer cell line
G Pappa, H Bartsch… - Molecular nutrition & food …, 2007 - Wiley Online Library
Sulforaphane (SFN), a cancer chemopreventive compound derived from broccoli, is able to
induce cell cycle arrest and apoptosis in various tumor cell lines. Here we show that cell …
induce cell cycle arrest and apoptosis in various tumor cell lines. Here we show that cell …
Adaptive response to GSH depletion and resistance to l-buthionine-(S,R)-sulfoximine: involvement of Nrf2 activation
HR Lee, JM Cho, D Shin, CS Yong, HG Choi… - Molecular and cellular …, 2008 - Springer
Pharmacological depletion of l-γ-glutamyl-l-cysteinyl-glycine (GSH) has been implicated in
the sensitization of cancer cells to alkylating agents and apoptosis. However, some types of …
the sensitization of cancer cells to alkylating agents and apoptosis. However, some types of …
Role of Lipid Peroxidation in Cellular Responses to d,l-Sulforaphane, a Promising Cancer Chemopreventive Agent
R Sharma, A Sharma, P Chaudhary, V Pearce… - Biochemistry, 2010 - ACS Publications
d, l-Sulforaphane (SFN), a synthetic analogue of the broccoli-derived l-isomer, is a highly
promising cancer chemopreventive agent substantiated by inhibition of chemically induced …
promising cancer chemopreventive agent substantiated by inhibition of chemically induced …
Anticancer activity of sulforaphane: the epigenetic mechanisms and the Nrf2 signaling pathway
X Su, X Jiang, L Meng, X Dong… - Oxidative medicine and …, 2018 - Wiley Online Library
Sulforaphane (SFN), a compound derived from cruciferous vegetables that has been shown
to be safe and nontoxic, with minimal/no side effects, has been extensively studied due to its …
to be safe and nontoxic, with minimal/no side effects, has been extensively studied due to its …
Sulforaphane suppresses TNF-α-mediated activation of NF-κB and induces apoptosis through activation of reactive oxygen species-dependent caspase-3
DO Moon, MO Kim, SH Kang, YH Choi, GY Kim - Cancer letters, 2009 - Elsevier
Sulforaphane (SFN) is a biologically active compound extracted from cruciferous
vegetables, and possessing potent anti-cancer and anti-inflammatory activities. Here, we …
vegetables, and possessing potent anti-cancer and anti-inflammatory activities. Here, we …
Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cells
MJ Kim, SH Kim, SJ Lim - Anticancer research, 2010 - ar.iiarjournals.org
The anticancer activity of sulforaphane is known to be mediated at least partly by apoptosis
induction and associated with the presence of the–N= C= S moiety. The present study …
induction and associated with the presence of the–N= C= S moiety. The present study …
相关搜索
- gene expression and apoptosis
- effects of glutathione gene expression
- tnf α caspase 3
- nf κb caspase 3
- oxygen species cell death
- metallothionein expression effect of sulforaphane
- antioxidant effects hepg2 cells
- metallothionein expression induction of apoptosis
- antioxidant effects immortalised hepatocytes
- gsh depletion adaptive response
- nrf2 activation adaptive response
- cellular responses lipid peroxidation
- effect of sulforaphane hepg2 cells
- metallothionein expression hepg2 cells