Objective This study was undertaken to investigate the effect of long-term amiodarone
administration and withdrawal on the histological structure of rat lung. In addition, the …

Amiodarone is a highly effective anti-arrhythmic drug, used in the treatment of cardiac
arrhythmias. However, it is of a limited use due its serious side effects especially lung …

Background: Chronic interstitial pneumonitis is the most common presentation of
amiodarone-induced pulmonary disease. Aim of the work: To throw a light on the damage of …

This study was designed to specify the toxicity of amiodarone toward mouse pulmonary
endothelial cells in comparison with that of another cationic amphiphilic drug, ie, mianserin …

Amiodarone is a potent antiarrhythmic agent with a number of side-effects, the most serious
being the development of pulmonary toxicity. The purpose of the study was to determine if a …

Conclusions Since the discovery of amiodarone over 30 years ago, the mechanisms
underlying serious adverse effects remain to be resolved and still limit drug usefulness …

Amiodarone is an antiarrhythmic drug with numerous side effects, the most serious being the
development of pulmonary toxicity. We have previously reported that a single intratra cheal …

Amiodarone‐(AM‐) induced pulmonary toxicity (AIPT) is still a matter of research and is
poorly understood. In attempting to resolve this issue, we treated Sprague‐Dawley rats with …

Materials and Methods: Twelve male albino rats were divided into three groups (ml
vegetable oil/day by oral gavages daily for 2 weeks and were used as control group. The …

Toinvestigate the hypotheses that amiodarone-induced pulmonary inflammation may be
related to direct drug toxicity, groups of 10or more Wistar rats were fed amiodarone by …