Enhanced diffusion in active intracellular transport

A Caspi, R Granek, M Elbaum - Physical review letters, 2000 - APS
We show that within a living eukaryotic cell, mean square displacement of an engulfed
microsphere shows enhanced diffusion scaling as t 3/2 at short times, with a clear crossover …

Diffusion and directed motion in cellular transport

A Caspi, R Granek, M Elbaum - Physical Review E, 2002 - APS
We study the motion of a probe driven by microtubule-associated motors within a living
eukaryotic cell. The measured mean square displacement,< x (t) 2> of engulfed 2 and 3 μ m …

Intracellular transport by active diffusion

CP Brangwynne, GH Koenderink, FC MacKintosh… - Trends in cell …, 2009 - cell.com
All substances exhibit constant random motion at the microscopic scale. This is a direct
consequence of thermal agitation, and leads to diffusion of molecules and small particles in …

Temporal analysis of active and passive transport in living cells

D Arcizet, B Meier, E Sackmann, JO Rädler… - Physical review letters, 2008 - APS
The cellular cytoskeleton is a fascinating active network, in which Brownian motion is
intercepted by distinct phases of active transport. We present a time-resolved statistical …

[HTML][HTML] Cytoplasmic RNA-protein particles exhibit non-Gaussian subdiffusive behavior

TJ Lampo, S Stylianidou, MP Backlund, PA Wiggins… - Biophysical journal, 2017 - cell.com
The cellular cytoplasm is a complex, heterogeneous environment (both spatially and
temporally) that exhibits viscoelastic behavior. To further develop our quantitative insight into …

[HTML][HTML] Anomalous diffusion of single particles in cytoplasm

BM Regner, D Vučinić, C Domnisoru, TM Bartol… - Biophysical journal, 2013 - cell.com
The crowded intracellular environment poses a formidable challenge to experimental and
theoretical analyses of intracellular transport mechanisms. Our measurements of single …

[HTML][HTML] Diffusion within the cytoplasm: a mesoscale model of interacting macromolecules

F Trovato, V Tozzini - Biophysical journal, 2014 - cell.com
Recent experiments carried out in the dense cytoplasm of living cells have highlighted the
importance of proteome composition and nonspecific intermolecular interactions in …

[HTML][HTML] The effect of macromolecular crowding on mobility of biomolecules, association kinetics, and gene expression in living cells

M Tabaka, T Kalwarczyk, J Szymanski, S Hou… - Frontiers in …, 2014 - frontiersin.org
We discuss a quantitative influence of macromolecular crowding on biological processes:
motion, bimolecular reactions, and gene expression in prokaryotic and eukaryotic cells. We …

Anomalous transport in the crowded world of biological cells

F Höfling, T Franosch - Reports on Progress in Physics, 2013 - iopscience.iop.org
A ubiquitous observation in cell biology is that the diffusive motion of macromolecules and
organelles is anomalous, and a description simply based on the conventional diffusion …

Cytoplasmic diffusion: molecular motors mix it up

CP Brangwynne, GH Koenderink… - The Journal of cell …, 2008 - rupress.org
Random motion within the cytoplasm gives rise to molecular diffusion; this motion is
essential to many biological processes. However, in addition to thermal Brownian motion …