Multiple sclerosis (MS) is a debilitating neurological disorder of the central nervous system
(CNS), characterized by activation and infiltration of leukocytes and dendritic cells into the …

Multiple sclerosis (MS) is an autoimmune and neurodegenerative disorder characterized by
chronic inflammation, demyelination, as well as axonal and neuronal loss in the central …

Multiple sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous
system (CNS) characterized by loss of myelin accompanied by infiltration of T‐lymphocytes …

In the human disorder multiple sclerosis (MS) and in the model experimental autoimmune
encephalomyelitis (EAE), macrophages predominate in demyelinated areas and their …

Microglial cells are central nervous system (CNS) resident cells that are thought to become
activated and contribute to the inflammation that occurs in the human autoimmune disease …

In multiple sclerosis and the experimental autoimmune encephalomyelitis (EAE) model, both
resident microglia and infiltrating macrophages contribute to demyelination as well as …

Macrophages can be of dual origin. Most tissue-resident macrophage compartments are
generated before birth and subsequently maintain themselves independently from each …

The central nervous system (CNS) is immune privileged with access to leukocytes being
limited. In several neurological diseases, however, infiltration of immune cells from the …

Microglia are the resident macrophages of the central nervous system (CNS). They have
important physiological functions in maintaining tissue homeostasis but also contribute to …

Inflammation is a series of processes designed for eventual clearance of pathogens and
repair of damaged tissue. In the context of autoimmune recognition, inflammatory processes …