Multiple sclerosis: experimental models and reality

H Lassmann, M Bradl - Acta neuropathologica, 2017 - Springer
One of the most frequent statements, provided in different variations in the introduction of
experimental studies on multiple sclerosis (MS), is that “Multiple sclerosis is a demyelinating …

The immune response in multiple sclerosis

S Rodríguez Murúa, MF Farez… - Annual Review of …, 2022 - annualreviews.org
Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative
disease that affects the central nervous system (CNS). MS is characterized by immune …

New insights into the role of IL-1β in experimental autoimmune encephalomyelitis and multiple sclerosis

CC Lin, BT Edelson - The Journal of Immunology, 2017 - journals.aai.org
Multiple sclerosis (MS), and its animal model experimental autoimmune encephalomyelitis,
are neuroinflammatory diseases driven by autoreactive pathogenic TH cells that elicit …

Mechanisms regulating regional localization of inflammation during CNS autoimmunity

E Pierson, SB Simmons, L Castelli… - Immunological …, 2012 - Wiley Online Library
Multiple sclerosis (MS) is a disease of the central nervous system (CNS) characterized by
inflammatory, demyelinating lesions localized in the brain and spinal cord. Experimental …

Diversity of immune cell types in multiple sclerosis and its animal model: Pathological and therapeutic implications

Y Cheng, L Sun, Z Xie, X Fan, Q Cao… - Journal of …, 2017 - Wiley Online Library
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous
system with an autoimmune attack on the components of the myelin sheath and axons. The …

Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status

D Vogel, EJF Vereyken, JE Glim, PDAM Heijnen… - Journal of …, 2013 - Springer
Background Macrophages play a dual role in multiple sclerosis (MS) pathology. They can
exert neuroprotective and growth promoting effects but also contribute to tissue damage by …

The role of microglia in multiple sclerosis

C Luo, C Jian, Y Liao, Q Huang, Y Wu… - Neuropsychiatric …, 2017 - Taylor & Francis
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS).
Microglia are the resident innate immune cells in the CNS; they play an important role in the …

Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion

JR Plemel, JA Stratton, NJ Michaels, KS Rawji… - Science …, 2020 - science.org
Microglia and infiltrating macrophages are thought to orchestrate the central nervous system
(CNS) response to injury; however, the similarities between these cells make it challenging …

Myeloid‐derived suppressor cells support remyelination in a murine model of multiple sclerosis by promoting oligodendrocyte precursor cell survival, proliferation, and …

C Melero‐Jerez, B Fernández‐Gómez… - Glia, 2021 - Wiley Online Library
The most frequent variant of multiple sclerosis (MS) is the relapsing–remitting form,
characterized by symptomatic phases followed by periods of total/partial recovery. Hence, it …

A case for regulatory B cells in controlling the severity of autoimmune-mediated inflammation in experimental autoimmune encephalomyelitis and multiple sclerosis

A Ray, MK Mann, S Basu, BN Dittel - Journal of neuroimmunology, 2011 - Elsevier
Multiple sclerosis (MS) is considered to be a T cell-mediated autoimmune disease that
results in the presence of inflammatory lesions/plaques associated with mononuclear cell …