THE E7 transforming protein of human papilloma virus-16 binds to the retinoblastoma gene
product (pRb) 1, 2 through a nine-amino-acid segment of E7 (21–29) 3–5. This segment of …

The retinoblastoma gene product, pRB, regulates cell proliferation by binding to and
inhibiting the activity of key growth promoting proteins. Several cellular proteins have been …

Transformation of mammalian cells by human papillomavirus type 16 appears to require
binding of the viral E7 protein to the cellular retinoblastoma growth suppressor gene product …

We have previously identified a small-cell lung cancer cell line (NCI-H209) that expresses
an aberrant, underphosphorylated form of the retinoblastoma protein RB1. Molecular …

Deletions or mutations of the retinoblastoma gene, RB1, are common features of many
tumors and tumor cell lines. Recently, the RB1 gene product, p105-RB, has been shown to …

The human papillomaviruses (HPVs) associated with genital tract lesions can be classified
as either" high risk" or" low risk" based on their association with human anogenital cancer …

The E7 proteins encoded by the human papillomaviruses (HPVs) associated with anogenital
lesions share significant amino acid sequence homology. The E7 proteins of these different …

Mutational inactivation of the retinoblastoma (RB) gene has been implicated in the genesis
of retinoblastoma, osteosarcoma, and other human tumors. Our strategy has been to …

Even though the retinoblastoma gene is one of the best-studied tumor suppressor genes,
little is known about its functional role. Like all tumor suppressor gene products, the …

Studies of adenovirus E1A oncoprotein mutants suggest that the association of E1A with the
retinoblastoma protein (pRB) is necessary for E1A-mediated transformation. Mutational …