MicroRNA functions in animal development and human disease

I Alvarez-Garcia, EA Miska - 2005 - journals.biologists.com
Five years into thesmall RNA revolution'it is hard not to share in the excitement about the
rapidly unravelling biology of microRNAs. Since the discovery of the first microRNA gene, lin …

MicroRNAs: small RNAs with a big role in gene regulation

L He, GJ Hannon - Nature reviews genetics, 2004 - nature.com
MicroRNAs are a family of small, non-coding RNAs that regulate gene expression in a
sequence-specific manner. The two founding members of the microRNA family were …

How microRNAs control cell division, differentiation and death

EA Miska - Current opinion in genetics & development, 2005 - Elsevier
After the milestone discovery of the first microRNA in 1993, the past five years have seen a
phenomenal surge of interest in these short, regulatory RNAs. Given that 2% of all known …

Mammalian microRNAs: a small world for fine-tuning gene expression

C Sevignani, GA Calin, LD Siracusa, CM Croce - Mammalian genome, 2006 - Springer
The basis of eukaryotic complexity is an intricate genetic architecture where parallel systems
are involved in tuning gene expression, via RNA-DNA, RNA-RNA, RNA-protein, and DNA …

Mechanisms of microRNA-mediated gene regulation in animal cells

TW Nilsen - TRENDS in Genetics, 2007 - cell.com
MicroRNAs are a large family of regulatory molecules found in all multicellular organisms.
Even though their functions are only beginning to be understood, it is evident that …

MicroRNA—implications for cancer

S Sassen, EA Miska, C Caldas - Virchows Archiv, 2008 - Springer
MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression post-
transcriptionally. After the discovery of the first miRNA in the roundworm Caenorhabditis …

MicroRNAs and cancer: a long story for short RNAs

A Drusco, CM Croce - Advances in cancer research, 2017 - Elsevier
More than six decades ago Watson and Crick published the chemical structure of DNA. This
discovery revolutionized our approach to medical science and opened new perspectives for …

[HTML][HTML] MicroRNAs: genomics, biogenesis, mechanism, and function

DP Bartel - cell, 2004 - cell.com
MicroRNAs (miRNAs) are endogenous∼ 22 nt RNAs that can play important regulatory
roles in animals and plants by targeting mRNAs for cleavage or translational repression …

The multifaceted roles of microRNAs in differentiation

H Galagali, JK Kim - Current opinion in cell biology, 2020 - Elsevier
MicroRNAs (miRNAs) are major drivers of cell fate specification and differentiation. The post-
transcriptional regulation of key molecular factors by microRNAs contributes to the …

The microRNAs of Caenorhabditis elegans

LP Lim, NC Lau, EG Weinstein… - Genes & …, 2003 - genesdev.cshlp.org
MicroRNAs (miRNAs) are an abundant class of tiny RNAs thought to regulate the expression
of protein-coding genes in plants and animals. In the present study, we describe a …