From studies using macrovascular endothelium, it was concluded that Rho A activation
generally leads to endothelial barrier breakdown. Here, we characterized the role of Rho …

RhoGTPases are known regulators of intracellular actin dynamics that are important for
maintaining endothelial barrier function. RhoA is most extensively studied as a key regulator …

We have demonstrated previously that the Rho family GTPase Rac-1 is required for
maintenance of endothelial barrier functions in mouse microvascular myocardial endothelial …

In the past decade understanding of the role of the Rho GTPases RhoA, Rac1 and Cdc42
has been developed from regulatory proteins that regulate specific actin cytoskeletal …

Endothelial barrier dysfunction underlies chronic inflammatory diseases. In searching for
new proteins essential to the human endothelial inflammatory response, we have found that …

Objective—Rho kinase mediates vascular leakage caused by many vasoactive agents
including thrombin. Enhanced Rho kinase activity induces endothelial barrier dysfunction by …

Previous experiments using cultured endothelial monolayers indicate that Rho‐family small
GTPases are involved in modulation of endothelial monolayer permeability by regulating …

Rap1 and Rap2 are closely related proteins of the Ras family of small G-proteins. Rap1 is
well known to regulate cell-cell adhesion. Here, we have analysed the effect of Rap …

Endothelial permeability depends on the integrity of intercellular junctions as well as
actomyosin-based cell contractility. Rho GTPases have been implicated in signalling by …

Inflammatory mediators increase vascular permeability primarily by formation of intercellular
gaps between endothelial cells of post-capillary venules. Under these conditions …