Identification and characterization of a novel folliculin-interacting protein FNIP2
Birt–Hogg–Dube'syndrome characterized by increased risk for renal neoplasia is caused by
germline mutations in the BHD/FLCN gene encoding a novel tumor suppressor protein …
germline mutations in the BHD/FLCN gene encoding a novel tumor suppressor protein …
Renal tumour suppressor function of the Birt–Hogg–Dubé syndrome gene product folliculin
V Hudon, S Sabourin, AB Dydensborg… - Journal of medical …, 2010 - jmg.bmj.com
Background Renal cell carcinoma (RCC) comprises five major molecular and histological
subtypes. The Birt–Hogg–Dubé (BHD) syndrome is a hereditary human cancer syndrome …
subtypes. The Birt–Hogg–Dubé (BHD) syndrome is a hereditary human cancer syndrome …
Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn
Folliculin (FLCN)-interacting proteins 1 and 2 (FNIP1, FNIP2) are homologous binding
partners of FLCN, a tumor suppressor for kidney cancer. Recent studies have revealed …
partners of FLCN, a tumor suppressor for kidney cancer. Recent studies have revealed …
Molecular genetics and clinical features of Birt–Hogg–Dubé syndrome
LS Schmidt, WM Linehan - Nature Reviews Urology, 2015 - nature.com
Abstract Birt–Hogg–Dubé (BHD) syndrome is an inherited renal cancer syndrome in which
affected individuals are at risk of developing benign cutaneous fibrofolliculomas, bilateral …
affected individuals are at risk of developing benign cutaneous fibrofolliculomas, bilateral …
The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dube syndrome is required for murine B-cell development
Abstract Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant disorder characterized
by cutaneous fibrofolliculomas, pulmonary cysts, and kidney malignancies. Affected …
by cutaneous fibrofolliculomas, pulmonary cysts, and kidney malignancies. Affected …
Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-β signaling
SB Hong, HB Oh, VA Valera, J Stull, DT Ngo, M Baba… - Molecular cancer, 2010 - Springer
Background Germline mutations in the FLCN gene are responsible for the development of
fibrofolliculomas, lung cysts and renal neoplasia in Birt-Hogg-Dube'(BHD) syndrome. The …
fibrofolliculomas, lung cysts and renal neoplasia in Birt-Hogg-Dube'(BHD) syndrome. The …
Birt–Hogg–Dube syndrome: clinical and molecular aspects of recently identified kidney cancer syndrome
Abstract Birt–Hogg–Dubé syndrome is an autosomal dominantly inherited disease that
predisposes patients to develop fibrofolliculoma, lung cysts and bilateral multifocal renal …
predisposes patients to develop fibrofolliculoma, lung cysts and bilateral multifocal renal …
FLCN: the causative gene for Birt-Hogg-Dubé syndrome
LS Schmidt, WM Linehan - Gene, 2018 - Elsevier
Germline mutations in the novel tumor suppressor gene FLCN are responsible for the
autosomal dominant inherited disorder Birt-Hogg-Dubé (BHD) syndrome that predisposes to …
autosomal dominant inherited disorder Birt-Hogg-Dubé (BHD) syndrome that predisposes to …
Birt–Hogg–Dubé syndrome: from gene discovery to molecularly targeted therapies
LS Schmidt - Familial cancer, 2013 - Springer
Since the hallmark dermatologic features of Birt–Hogg–Dubé (BHD) syndrome were first
described by three Canadian physicians in 1977, the clinical manifestations of BHD have …
described by three Canadian physicians in 1977, the clinical manifestations of BHD have …
Birt–Hogg–Dubé syndrome: clinicopathological features of the lung
M Furuya, Y Nakatani - Journal of Clinical pathology, 2013 - jcp.bmj.com
Birt–Hogg–Dubé syndrome (BHD) is an autosomal dominant inherited disorder
characterised by fibrofolliculomas, renal tumours, pulmonary cysts and pneumothorax. The …
characterised by fibrofolliculomas, renal tumours, pulmonary cysts and pneumothorax. The …