Stem Cells from the Apical Papilla (SCAPs): Past, Present, Prospects, and Challenges

Q Liu, Y Gao, J He - Biomedicines, 2023 - mdpi.com
Dental diseases occurring on young permanent teeth usually lead to the premature arrest of
tooth root development. Sustained tooth root elongation is necessary to achieve the goal of …

Stem cells from the apical papilla: A promising source for stem cell‐based therapy

J Kang, W Fan, Q Deng, H He… - BioMed research …, 2019 - Wiley Online Library
Stem cells are biological cells that can self‐renew and can differentiate into multiple cell
lineages. Stem cell‐based therapy is emerging as a promising alternative therapeutic option …

Survival of the apical papilla and its resident stem cells in a case of advanced pulpal necrosis and apical periodontitis

V Chrepa, B Pitcher, MA Henry, A Diogenes - Journal of endodontics, 2017 - Elsevier
Introduction Apical papilla represents a source of an enriched mesenchymal stem cell
(MSC) population (stem cells of the apical papilla [SCAPs]) that modulates root development …

Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study

W Sonoyama, Y Liu, T Yamaza, RS Tuan, S Wang… - Journal of …, 2008 - Elsevier
Mesenchymal stem cells (MSCs) have been isolated from the pulp tissue of permanent teeth
(dental pulp stem cells or DPSCs) and deciduous teeth (stem cells from human exfoliated …

The hidden treasure in apical papilla: the potential role in pulp/dentin regeneration and bioroot engineering

GTJ Huang, W Sonoyama, Y Liu, H Liu, S Wang… - Journal of …, 2008 - Elsevier
Some clinical case reports have shown that immature permanent teeth with periradicular
periodontitis or abscess can undergo apexogenesis after conservative endodontic …

Stem cells from the apical papilla (SCAP) as a tool for endogenous tissue regeneration

OA Nada, RM El Backly - Frontiers in bioengineering and …, 2018 - frontiersin.org
Stem cells extracted from developing tissues possibly exhibit not only unique but also
superior traits against their developed counterparts. Indeed, stem cells from the apical …

Characterization of a stem cell of apical papilla cell line: effect of passage on cellular phenotype

NB Ruparel, JFA De Almeida, MA Henry… - Journal of …, 2013 - Elsevier
INTRODUCTION: Stem cells of the apical papilla (SCAP) have been identified as an
important population of mesenchymal stem cells (MSCs) in regenerative endodontics …

Acetylsalicylic acid treatment and suppressive regulation of AKT accelerate odontogenic differentiation of stem cells from the apical papilla

Y Tanaka, S Sonoda, H Yamaza, S Murata… - Journal of …, 2019 - Elsevier
Introduction Stem cells isolated from the root apical papilla of human teeth (stem cells from
the apical papilla [SCAPs]) are capable of forming tooth root dentin and are a feasible …

Molecular biological comparison of dental pulp-and apical papilla-derived stem cells

M Smeda, KM Galler, M Woelflick, A Rosendahl… - International Journal of …, 2022 - mdpi.com
Both the dental pulp and the apical papilla represent a promising source of mesenchymal
stem cells for regenerative endodontic protocols. The aim of this study was to outline …

Unraveling the role of the apical papilla during dental root maturation

RB Driesen, P Gervois, T Vangansewinkel… - Frontiers in Cell and …, 2021 - frontiersin.org
The apical papilla is a stem cell rich tissue located at the base of the developing dental root
and is responsible for the progressive elongation and maturation of the root. The multipotent …