The germinal center (GC) reaction underlies productive humoral immunity by orchestrating
competition-based affinity maturation to produce plasma cells and memory B cells. T cells …

Germinal centers play a key role in the adaptive immune system since they are able to
produce memory B cells and plasma cells that produce high affinity antibodies for an …

Germinal center (GC) reactions are vital to the correct functioning of the adaptive immune
system, through formation of high affinity, class switched antibodies. GCs are transient …

Germinal centers (GCs) are sites of B cell clonal expansion, diversification, and antibody
affinity selection. This process is limited and directed by T follicular helper cells that provide …

Highlights•Germinal centers (GCs) facilitate antigen-specific evolution of B cell
repertoire.•Follicular helper T cells regulate GC evolution, memory, and plasma cell …

The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid
tissues, producing long-lived antibody secreting plasma cells and memory B cells, which …

Germinal centers (GCs) are transient anatomical microenvironments where antibody affinity
maturation and memory B cells generation takes place. In the past, models of Germinal …

Inside germinal centers (GCs), antigen-specific B cells rely on precise interactions with
immune cells and strategic localization between the dark and light zones to clonally expand …

Follicular T‐helper (TFH) cells play a crucial role in three aspects of the germinal center
(GC) response. They promote GC formation, arbitrate competition among GC B cells to …

Germinal centers (GCs) are specialized compartments within the secondary lymphoid
organs where B cells proliferate, differentiate, and mutate their antibody genes in response …