Mechanisms of key innate immune cells in early-and late-onset preeclampsia

I Aneman, D Pienaar, S Suvakov, TP Simic… - Frontiers in …, 2020 - frontiersin.org
Preeclampsia is a complex cardiovascular disorder of pregnancy with underlying
multifactorial pathogeneses; however, its etiology is not fully understood. It is characterized …

Cellular immune responses in the pathophysiology of preeclampsia

D Miller, K Motomura, J Galaz… - Journal of Leukocyte …, 2022 - academic.oup.com
Preeclampsia, defined as new-onset hypertension accompanied by proteinuria occurring at
20 weeks of gestation or later, is a leading cause of perinatal morbidity and mortality …

Innate immunity, decidual cells, and preeclampsia

CC Yeh, KC Chao, SJ Huang - Reproductive Sciences, 2013 - journals.sagepub.com
Preeclampsia (PE) manifested by hypertension and proteinuria complicates 3% to 8% of
pregnancies and is a leading cause of fetal–maternal morbidity and mortality worldwide. It …

Disruption in the regulation of immune responses in the placental subtype of preeclampsia

J Geldenhuys, TM Rossouw, HA Lombaard… - Frontiers in …, 2018 - frontiersin.org
Preeclampsia is a pregnancy-specific disorder, of which one of its major subtypes, the
placental subtype is considered a response to an ischemic placental environment, impacting …

Preeclampsia: from inflammation to immunoregulation

DC Cornelius - Clinical medicine insights: Blood disorders, 2018 - journals.sagepub.com
Preeclampsia (PE) affects 5% to 7% of pregnant women each year worldwide, accounts for
up to 18% of maternal deaths in the United States each year, and is the number 1 cause of …

Elucidating immune mechanisms causing hypertension during pregnancy

B LaMarca, D Cornelius, K Wallace - Physiology, 2013 - journals.physiology.org
Preeclampsia is associated with hypertension and increased infant and maternal morbidity
and mortality. The underlying cause of preeclampsia is largely unknown, but it is clear that …

The role of immune cells and mediators in preeclampsia

E Deer, O Herrock, N Campbell, D Cornelius… - Nature Reviews …, 2023 - nature.com
Preeclampsia is a hypertensive disorder of major concern in pregnancy than can lead to
intrauterine growth restriction, placental abruption and stillbirth. The pathophysiology of …

Review of the immune mechanisms of preeclampsia and the potential of immune modulating therapy

YC Ai-ris, LA Smith, SA Karumanchi - Human immunology, 2021 - Elsevier
Successful pregnancy relies on maternal immunologic tolerance mechanisms limit
maladaptive immune responses against the semi-allogeneic fetus and placenta and support …

The role of immunity in the pathogenesis and development of pre‐eclampsia

HQ Lu, R Hu - Scandinavian journal of immunology, 2019 - Wiley Online Library
Pre‐eclampsia (PE) is a leading cause of maternal and perinatal morbidity and mortality;
however, the aetiology of PE still remains unclear. It has been widely accepted that the …

Resolution of inflammation pathways in preeclampsia—a narrative review

LO Perucci, MD Corrêa, LM Dusse, KB Gomes… - Immunologic …, 2017 - Springer
Preeclampsia (PE) is one of the leading causes of maternal morbidity and mortality
worldwide. This disease is believed to occur in two stages with placental dysfunction in early …