To assess biological roles of the retinoblastoma protein (RB), four independent transgenic
mouse lines expressing human RB with different deletions in the N-terminal region (RBΔN) …

To study the molecular basis for the clinical phenotype of incomplete penetrance of familial
retinoblastoma, we have examined the functional properties of three RB mutations identified …

The identification of the retinoblastoma gene (rb) has sparked intense inves tigation of tumor
suppressor genes. These genes, like oncogenes, can encode transcriptional regulators …

The Rb gene was isolated almost 20 years ago, but fundamental questions regarding its role
in retinal development and retinoblastoma remain. What is the normal function of RB protein …

Since its discovery, the retinoblastoma (RB) tumour-suppressor protein has been a focal
point of cancer research. Accumulating evidence indicates a complex role for RB in cell …

Abstract Rb+/+: Rb−/− chimeric mice are healthy until early in adulthood when they develop
lethal pituitary tumors composed solely of Rb−/− cells. In an effort to delineate the minimal …

Retinoblastoma is a malignant tumor of the retina that occurs primarily in young children as
a result of mutations in the retinoblastoma gene (RB), the first tumor suppressor gene to be …

Abstract Models for studying the quantitative effects of RB protein in development and in
tumorigenesis have been constructed. By crossing transgenic mice carrying the human Rb …

We report differential expression of the RB1 tumor suppressor gene and the homologous
genes p107 and p130 during embryogenesis. Abundant RB1 transcripts were detected …

Mutational inactivation of the retinoblastoma gene (RB) is an invariant feature of the
childhood eye cancer retinoblastoma and of tumor cells derived therefrom. In a previous …