Uropathogenic Escherichia coli account for the largest proportion of nosocomial infections in
the United States. Nosocomial infections are a major source of increased costs and …

Biofilm-associated microbes are 10–1000 times less susceptible to antibiotics. An emerging
treatment strategy is to target the structural components of biofilm to weaken the extracellular …

Curli amyloid fibrils secreted by Enterobacteriaceae mediate host cell adhesion and
contribute to biofilm formation, thereby promoting bacterial resistance to environmental …

Escherichia coli assemble functional amyloid fibers termed curli that contribute to bacterial
adhesion, biofilm formation, and host pathogenesis. We developed a cell-based high …

Functional bacterial amyloid provides structural stability in biofilm, making it a promising
target for anti-biofilm therapeutics. Fibrils formed by CsgA, the major amyloid component in …

The escalating threat of antimicrobial resistance has increased pressure to develop novel
therapeutic strategies to tackle drug-resistant infections. Antimicrobial peptides have …

Escherichia coli biofilms consist of bacteria embedded in a self‐produced matrix mainly
made of protein fibers and polysaccharides. The curli amyloid fibers found in the biofilm …

Escherichia coli and other Enterobacteriaceae thrive in robust biofilm communities through
the coproduction of curli amyloid fibers and phosphoethanolamine cellulose. Curli promote …

Curli are functional extracellular amyloid fibers produced by uropathogenic Escherichia coli
(UPEC) and other Enterobacteriaceae. Ring-fused 2-pyridones, such as FN075 and BibC6 …

Nosocomial infections affect hundreds of millions of patients worldwide each year, and~
60% of these infections are associated with biofilm formation on an implanted medical …