Targeting HGF/c-MET axis in pancreatic cancer
Pancreatic cancer (pancreatic ductal adenocarcinoma (PDAC/PC)) has been an aggressive
disease that is associated with early metastases. It is characterized by dense and …
disease that is associated with early metastases. It is characterized by dense and …
[HTML][HTML] Targeting the HGF/c-MET pathway: stromal remodelling in pancreatic cancer
Stromal-tumor interactions in pancreatic cancer (PC) impact on treatment outcomes.
Pancreatic stellate cells (PSCs) produce the collagenous stroma of PC and interact with …
Pancreatic stellate cells (PSCs) produce the collagenous stroma of PC and interact with …
MET/HGF co-targeting in pancreatic cancer: a tool to provide insight into the tumor/stroma crosstalk
C Modica, D Tortarolo, PM Comoglio… - International journal of …, 2018 - mdpi.com
The 'onco-receptor'MET (Hepatocyte Growth Factor Receptor) is involved in the activation of
the invasive growth program that is essential during embryonic development and critical for …
the invasive growth program that is essential during embryonic development and critical for …
Hepatocyte growth factor from a clinical perspective: A pancreatic cancer challenge
W Rizwani, AE Allen, JG Trevino - Cancers, 2015 - mdpi.com
Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States
and incidence rates are rising. Both detection and treatment options for pancreatic cancer …
and incidence rates are rising. Both detection and treatment options for pancreatic cancer …
Targeting the HGF/c-MET pathway in advanced pancreatic cancer: A key element of treatment that limits primary tumour growth and eliminates metastasis
Background Stromal–tumour interactions facilitate pancreatic cancer (PC) progression. The
hepatocyte growth factor (HGF)/c-MET pathway is upregulated in PC and mediates the …
hepatocyte growth factor (HGF)/c-MET pathway is upregulated in PC and mediates the …
Hepatocyte growth factor inhibition: a novel therapeutic approach in pancreatic cancer
Background: Pancreatic stellate cells (PSCs, which produce the stroma of pancreatic cancer
(PC)) interact with cancer cells to facilitate PC growth. A candidate growth factor pathway …
(PC)) interact with cancer cells to facilitate PC growth. A candidate growth factor pathway …
Correlation between hypoxia and HGF/c-MET expression in the management of pancreatic cancer
Pancreatic cancer (PC) is very deadly and difficult to treat. The presence of hypoxia has
been shown to increase the probability of cancer developing and spreading. Pancreatic …
been shown to increase the probability of cancer developing and spreading. Pancreatic …
Targeting the HGF‐cMET axis in hepatocellular carcinoma
NK Venepalli, L Goff - International journal of hepatology, 2013 - Wiley Online Library
Under normal physiological conditions, the hepatocyte growth factor (HGF) and its receptor,
the MET transmembrane tyrosine kinase (cMET), are involved in embryogenesis …
the MET transmembrane tyrosine kinase (cMET), are involved in embryogenesis …
HGF/c-MET axis in tumor microenvironment and metastasis formation
A Spina, V De Pasquale, G Cerulo, P Cocchiaro… - Biomedicines, 2015 - mdpi.com
Tumor metastases are responsible for approximately 90% of all cancer-related deaths.
Metastasis formation is a multistep process that requires acquisition by tumor cells of a …
Metastasis formation is a multistep process that requires acquisition by tumor cells of a …
Dual inhibition of Hedgehog and c-Met pathways for pancreatic cancer treatment
AA Rucki, Q Xiao, S Muth, J Chen, X Che… - Molecular cancer …, 2017 - AACR
Pancreatic ductal adenocarcinoma (PDAC) is one of the most chemotherapy-and
radiotherapy-resistant tumors. The c-Met and Hedgehog (Hh) pathways have been shown …
radiotherapy-resistant tumors. The c-Met and Hedgehog (Hh) pathways have been shown …