Fecal virome transplantation is sufficient to alter fecal microbiota and drive lean and obese body phenotypes in mice
The gastrointestinal microbiome plays a significant role in modulating numerous host
processes, including metabolism. Prior studies show that when mice receive fecal …
processes, including metabolism. Prior studies show that when mice receive fecal …
Faecal virome transplantation decreases symptoms of type 2 diabetes and obesity in a murine model
Objective Development of obesity and type 2 diabetes (T2D) are associated with gut
microbiota (GM) changes. The gut viral community is predominated by bacteriophages …
microbiota (GM) changes. The gut viral community is predominated by bacteriophages …
Transfer of modified gut viromes improves symptoms associated with metabolic syndrome in obese male mice
X Mao, SB Larsen, LSF Zachariassen, A Brunse… - Nature …, 2024 - nature.com
Metabolic syndrome encompasses amongst other conditions like obesity and type-2
diabetes and is associated with gut microbiome (GM) dysbiosis. Fecal microbiota …
diabetes and is associated with gut microbiome (GM) dysbiosis. Fecal microbiota …
Basal diet determined long-term composition of the gut microbiome and mouse phenotype to a greater extent than fecal microbiome transfer from lean or obese …
DM Rodriguez, AD Benninghoff, NDJ Aardema… - Nutrients, 2019 - mdpi.com
The Western dietary pattern can alter the gut microbiome and cause obesity and metabolic
disorders. To examine the interactions between diet, the microbiome, and obesity, we …
disorders. To examine the interactions between diet, the microbiome, and obesity, we …
Prolonged transfer of feces from the lean mice modulates gut microbiota in obese mice
M Kulecka, A Paziewska, N Zeber-Lubecka… - Nutrition & …, 2016 - Springer
Background Transplanting a fecal sample from lean, healthy donors to obese recipients has
been shown to improve metabolic syndrome symptoms. We therefore examined the gut …
been shown to improve metabolic syndrome symptoms. We therefore examined the gut …
Fecal viral community responses to high-fat diet in mice
A Schulfer, TM Santiago-Rodriguez, M Ly, JM Borin… - MSphere, 2020 - Am Soc Microbiol
Alterations in diet can have significant impact on the host, with high-fat diet (HFD) leading to
obesity, diabetes, and inflammation of the gut. Although membership and abundances in gut …
obesity, diabetes, and inflammation of the gut. Although membership and abundances in gut …
Gut check: testing a role for the intestinal microbiome in human obesity
JS Flier, JJ Mekalanos - Science translational medicine, 2009 - science.org
By using germ-free mice transplanted with human fecal microbiota, scientists show that a
high-fat, high-sugar diet durably changes the transplanted microbiome and that this diet …
high-fat, high-sugar diet durably changes the transplanted microbiome and that this diet …
Transplanting fecal virus-like particles reduces high-fat diet-induced small intestinal bacterial overgrowth in mice
Fecal microbiota transplantation (FMT) is an effective tool for treating Clostridium difficile
infection in the setting of dysbiosis of the intestinal microbiome. FMT for other forms of …
infection in the setting of dysbiosis of the intestinal microbiome. FMT for other forms of …
High fat diet drives obesity regardless the composition of gut microbiota in mice
S Rabot, M Membrez, F Blancher, B Berger, D Moine… - Scientific reports, 2016 - nature.com
The gut microbiota is involved in many aspects of host physiology but its role in body weight
and glucose metabolism remains unclear. Here we studied the compositional changes of …
and glucose metabolism remains unclear. Here we studied the compositional changes of …
Fecal microbiota transplantation confers beneficial metabolic effects of diet and exercise on diet-induced obese mice
ZL Lai, CH Tseng, HJ Ho, CKY Cheung, JY Lin… - Scientific reports, 2018 - nature.com
Diet and exercise are conventional methods for controlling body weight and are linked to
alterations in gut microbiota. However, the associations of diet, exercise, and gut microbiota …
alterations in gut microbiota. However, the associations of diet, exercise, and gut microbiota …