Fecal virome transplantation is sufficient to alter fecal microbiota and drive lean and obese body phenotypes in mice

JM Borin, R Liu, Y Wang, TC Wu, J Chopyk… - Gut …, 2023 - Taylor & Francis
The gastrointestinal microbiome plays a significant role in modulating numerous host
processes, including metabolism. Prior studies show that when mice receive fecal …

Faecal virome transplantation decreases symptoms of type 2 diabetes and obesity in a murine model

TS Rasmussen, CMJ Mentzel, W Kot, JL Castro-Mejía… - Gut, 2020 - gut.bmj.com
Objective Development of obesity and type 2 diabetes (T2D) are associated with gut
microbiota (GM) changes. The gut viral community is predominated by bacteriophages …

Transfer of modified gut viromes improves symptoms associated with metabolic syndrome in obese male mice

X Mao, SB Larsen, LSF Zachariassen, A Brunse… - Nature …, 2024 - nature.com
Metabolic syndrome encompasses amongst other conditions like obesity and type-2
diabetes and is associated with gut microbiome (GM) dysbiosis. Fecal microbiota …

Basal diet determined long-term composition of the gut microbiome and mouse phenotype to a greater extent than fecal microbiome transfer from lean or obese …

DM Rodriguez, AD Benninghoff, NDJ Aardema… - Nutrients, 2019 - mdpi.com
The Western dietary pattern can alter the gut microbiome and cause obesity and metabolic
disorders. To examine the interactions between diet, the microbiome, and obesity, we …

Prolonged transfer of feces from the lean mice modulates gut microbiota in obese mice

M Kulecka, A Paziewska, N Zeber-Lubecka… - Nutrition & …, 2016 - Springer
Background Transplanting a fecal sample from lean, healthy donors to obese recipients has
been shown to improve metabolic syndrome symptoms. We therefore examined the gut …

Fecal viral community responses to high-fat diet in mice

A Schulfer, TM Santiago-Rodriguez, M Ly, JM Borin… - MSphere, 2020 - Am Soc Microbiol
Alterations in diet can have significant impact on the host, with high-fat diet (HFD) leading to
obesity, diabetes, and inflammation of the gut. Although membership and abundances in gut …

Gut check: testing a role for the intestinal microbiome in human obesity

JS Flier, JJ Mekalanos - Science translational medicine, 2009 - science.org
By using germ-free mice transplanted with human fecal microbiota, scientists show that a
high-fat, high-sugar diet durably changes the transplanted microbiome and that this diet …

Transplanting fecal virus-like particles reduces high-fat diet-induced small intestinal bacterial overgrowth in mice

DM Lin, B Koskella, NL Ritz, D Lin… - Frontiers in Cellular …, 2019 - frontiersin.org
Fecal microbiota transplantation (FMT) is an effective tool for treating Clostridium difficile
infection in the setting of dysbiosis of the intestinal microbiome. FMT for other forms of …

High fat diet drives obesity regardless the composition of gut microbiota in mice

S Rabot, M Membrez, F Blancher, B Berger, D Moine… - Scientific reports, 2016 - nature.com
The gut microbiota is involved in many aspects of host physiology but its role in body weight
and glucose metabolism remains unclear. Here we studied the compositional changes of …

Fecal microbiota transplantation confers beneficial metabolic effects of diet and exercise on diet-induced obese mice

ZL Lai, CH Tseng, HJ Ho, CKY Cheung, JY Lin… - Scientific reports, 2018 - nature.com
Diet and exercise are conventional methods for controlling body weight and are linked to
alterations in gut microbiota. However, the associations of diet, exercise, and gut microbiota …