Apoptosis is characterized by chromatin condensation, phosphatidylserine translocation,
and caspase activation. Neuronal apoptotic death involves the participation of reactive …

Sympathetic neurons in culture die by apoptosis when deprived of nerve growth factor
(NGF). We used this model of programmed cell death to study the mechanisms that mediate …

Free radicals and reactive oxygen species (ROS) are involved in a variety of different
cellular processes ranging from apoptosis and necrosis to cell proliferation and …

To investigate the involvement of reactive oxygen species (ROS) in neuronal apoptosis, we
performed confocal and flow cytometric analysis with a ROS-specific fluorogen, 6-carboxy …

When cultured cerebellar granule neurons (CGN) are transferred from 25 mM KCl (K25) to 5
mM KCl (K5) caspase‐3 and caspase‐8, but not caspase‐1 or caspase‐9, activities are …

Reactive oxygen species (ROS) have been implicated in the pathophysiology of many
neurologic disorders and brain dysfunction. In the same pathological settings evidence has …

A variety of neurodegenerative disease states have been associated with oxidative damage
or stress. Such stress is thought to be mediated by excessive exposure of cells to reactive …

Production of reactive oxygen intermediates (ROI) has been thought for a long time to
adversely affect the physiology and survival of a cell. There is now a growing body of …

Recently, reactive oxygen species (ROS) have been suggested as important mediators of
brain damage in a number of disease states, including traumatic brain injury …

To investigate whether direct oxidative damage may induce neuronal death via an apoptotic
cell suicide pathway, we exposed cultured cortical neurons to the prooxidant hydrogen …