Autism spectrum disorder (ASD) is a pervasive neurodevelopmental syndrome with a high
human and economic burden. The pathophysiology of ASD is largely unclear, thus …

Autism spectrum disorder (ASD) is a neurodevelopmental impairment characterized by
deficits in social interaction skills, impaired communication, and repetitive and restricted …

The excitatory‐inhibitory imbalance hypothesis postulates dysregulation of the gamma‐
aminobutyric acid (GABA) and glutamate (Glu) neurotransmitter systems as a common …

The balance of excitation and inhibition in neural circuits is hypothesized to be increased in
autism spectrum disorder, possibly mediated by altered signaling of the inhibitory …

Autism spectrum disorder (ASD) affects over 1: 100 of the population and costs the UK more
than£ 32bn and the USA more than $175 bn (£ 104bn) annually. Its core symptoms are …

Individuals on the autism spectrum are often reported as being hyper-and/or hyporeactive to
sensory input. These sensory symptoms were one of the key observations that led to the …

Dysfunctional glutamatergic neurotransmission has been implicated in autism spectrum
disorder (ASD). However, relatively few studies have directly measured brain glutamate in …

The gamma aminobutyric acid (GABA) neurotransmission system has been implicated in
autism spectrum disorder (ASD). Molecular neuroimaging studies incorporating …

BACKGROUND: Although brain imaging studies have reported neurobiological
abnormalities in autism, the nature and distribution of the underlying neurochemical …

Disturbances in the glutamatergic system have been increasingly documented in several
neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered …