The HIV-1 pandemic is a consequence of the cross-species transmission of simian
immunodeficiency virus in wild chimpanzees (SIVcpz) to humans. Our previous study …

The origins of human immunodeficiency virus type 1 (HIV-1) have been widely accepted to
be the consequences of simian immunodeficiency viruses from wild chimpanzees (SIVcpz) …

Human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS, originated from
simian immunodeficiency virus from chimpanzees (SIVcpz), the precursor of the human …

The genetic evolution of HIV-1 from its progenitor virus SIV following cross-species
transmission is not well understood. Here we simulated the SIVcpz initial transmission to …

HIV‐1 evolved from its progenitor SIV strains, but details are lacking on its adaptation to the
human host. We followed the evolution of SIVcpz in humanized mice to mimic cross‐species …

HIV‐1 evolved from SIV during cross‐species transmission events, though viral genetic
changes are not well understood. Here, we studied the evolution of SIVcpzLB715 into HIV‐1 …

HIV‐1 emerged from SIVcpz evolving in humans. Humanized mice are an effective tool for
assessing viral evolution via measuring viral loads, CD4+ T cell decline, and analyzing …

Current data suggest that the human immunodeficiency virus type 1 (HIV-1) epidemic arose
by transmission of simian immunodeficiency virus (SIV) SIVcpz from a subspecies of …

Background Simian immunodeficiency virus of chimpanzees (SIVcpz), the progenitor of
human immunodeficiency virus type 1 (HIV-1), is associated with increased mortality and …

Critical genetic adaptations needed for SIV chimpanzee to evolve into HIV‐1 are not well
understood. Using humanized mice, we mimicked the evolution of SIVcpzLB715 into HIV‐1 …