Zebrafish as a model to study the role of DNA methylation in environmental toxicology

JH Kamstra, P Aleström, JM Kooter, J Legler - Environmental Science and …, 2015 - Springer
Environmental epigenetics is a rapidly growing field which studies the effects of
environmental factors such as nutrition, stress, and exposure to compounds on epigenetic …

Environmental epigenetics in zebrafish

V Cavalieri, G Spinelli - Epigenetics & chromatin, 2017 - Springer
It is widely accepted that the epigenome can act as the link between environmental cues,
both external and internal, to the organism and phenotype by converting the environmental …

Epigenetic transgenerational modifications induced by xenobiotic exposure in zebrafish

L Terrazas-Salgado, A García-Gasca… - Frontiers in Cell and …, 2022 - frontiersin.org
Zebrafish (Danio rerio) is a well-established vertebrate model in ecotoxicology research that
responds to a wide range of xenobiotics such as pesticides, drugs, and endocrine-disrupting …

Patterns of DNA methylation in animals: an ecotoxicological perspective

JA Head - Integrative and Comparative Biology, 2014 - academic.oup.com
DNA methylation refers to the addition of a methyl group to nucleotides within DNA. As with
other epigenetic endpoints, patterns of DNA methylation are susceptible to alterations due to …

Epigenetic effects of environmental chemicals: insights from zebrafish

N Aluru - Current opinion in toxicology, 2017 - Elsevier
Zebrafish have been extensively used for studying vertebrate development and modeling
human diseases such as cancer. In the last two decades, they have also emerged as an …

Role of DNA methylation in altered gene expression patterns in adult zebrafish (Danio rerio) exposed to 3, 3', 4, 4', 5-pentachlorobiphenyl (PCB 126)

N Aluru, SI Karchner, KS Krick, W Zhu… - Environmental …, 2018 - academic.oup.com
There is growing evidence that environmental toxicants can affect various physiological
processes by altering DNA methylation patterns. However, very little is known about the …

Environmental chemicals differentially affect epigenetic-related mechanisms in the zebrafish liver (ZF-L) cell line and in zebrafish embryos

M Blanc, J Rüegg, N Scherbak, SH Keiter - Aquatic Toxicology, 2019 - Elsevier
A number of chemicals have been shown to affect epigenetic patterning and functions. Since
epigenetic mechanisms regulate transcriptional networks, epigenetic changes induced by …

DNA methylation and gene expression alterations in zebrafish early-life stages exposed to the antibacterial agent triclosan

E Falisse, B Ducos, PA Stockwell, IM Morison… - Environmental …, 2018 - Elsevier
There is increasing evidence that toxicant exposure can alter DNA methylation profile, one
of the main epigenetic mechanisms, particularly during embryogenesis when DNA …

Differential DNA methylation at conserved non-genic elements and evidence for transgenerational inheritance following developmental exposure to mono (2 …

JH Kamstra, LB Sales, P Aleström, J Legler - Epigenetics & chromatin, 2017 - Springer
Background Exposure to environmental stressors during development may lead to latent
and transgenerational adverse health effects. To understand the role of DNA methylation in …

Ionizing radiation induces transgenerational effects of DNA methylation in zebrafish

JH Kamstra, S Hurem, LM Martin, LC Lindeman… - Scientific reports, 2018 - nature.com
Ionizing radiation is known to cause DNA damage, yet the mechanisms underlying potential
transgenerational effects of exposure have been scarcely studied. Previously, we observed …