Here we develop a methylation editing toolbox, Casilio-ME, that enables not only RNA-
guided methylcytosine editing by targeting TET1 to genomic sites, but also by co-delivering …

Tools for actively targeted DNA demethylation are required to increase our knowledge about
regulation and specific functions of this important epigenetic modification. DNA …

Dear Editor, DNA methylation and demethylation play a critical role in regulating gene
expression as well as developmental and pathological processes 1. For example …

In mammalian cells, DNA methylation critically regulates gene expression and thus has
pivotal roles in myriad of physiological and pathological processes. Here we report a novel …

DNA methylation involves the enzymatic addition of a methyl group primarily to cytosine
residues in DNA. This protocol describes how to produce complete and minimally …

Abstract N1‐methyladenosine (m1A) is a prevalent and reversible RNA modification, which
plays a crucial role in the regulation of RNA fate and gene expression. However, the lack of …

RNA modification in the form of N 6-methyladenosine (m6A) regulates nearly all the post-
transcriptional processes. The asymmetric m6A deposition suggests that regional …

One key advantage of RNA over genomic editing is its temporary effects. Aside from current
use of DNA-targeting CRISPR-Cas9, the more recently discovered CRISPR-Cas13 has …

Despite four decades of research to support the association between DNA methylation and
gene expression, the causality of this relationship remains unresolved. Here, we reaffirm that …

Epigenetic studies relied so far on correlations between epigenetic marks and gene
expression pattern. Technologies developed for epigenome editing now enable direct study …