Mesoporous silica nanoparticles have attracted much attention in recent years as drug and
gene delivery systems for biomedical applications. Among their most beneficial features for …

DNA delivery is a core technology for gene structure and function research as well as
clinical settings. The ability to safely and efficiently targeted transfer foreign DNA into cells is …

The development of functional nanocarriers that can enhance the cellular delivery of a
variety of nucleic acid agents is important in many biomedical applications such as siRNA …

Human cervical cancer is the most common gynecological malignancy. The continuous
development of nanotechnology has allowed the wide use of nanomaterials in cancer …

A hollow mesoporous silica nanoparticle (HMSNP) based drug/siRNA co‐delivery system
was designed and fabricated, aiming at overcoming multidrug resistance (MDR) in cancer …

In this manuscript, we synthesized the potential non viral vector for gene delivery with proper
transfection efficiency and low cytotoxicity. Polyethylenimine (PEI) is a well‐known cationic …

Polyethylenimine (PEI), especially PEI 25 kDa, has been widely studied for delivery of
nucleic acid drugs both in vitro and in vivo. However, it lacks degradable linkages and is too …

Background To solve the efficiency versus cytotoxicity and tumor-targeting problems of
polyethylenimine (PEI) used as a nonviral gene delivery vector, a degradable PEI derivate …

Gene therapy using siRNA molecules is nowadays considered as a promising approach.
For successful therapy, development of a stable and reliable vector for siRNA is crucial. Non …

Branched polyethylenimine (PEI, 25kDa) was ionically interacted with varying amount of
alginic acid to block different proportion (2.6–5.7%) of amines in PEI to form a series of …