BACKGROUND AND OBJECTIVES: The chimeric product of the bcr-abl rearranged gene is
critical in the pathogenesis of chronic myeloid leukemia (CML), yet its role in the progression …

Polymerase chain reaction (PCR) is a powerful and rapid method for specifically detecting
BCR–ABL rearrangement by amplification of the complementary DNA (cDNA) produced by …

Very limited data exists in Thailand regarding the frequency of BCR-ABL leukemic gene and
its prognostic implication in Thai CML patients. The objective of this study was to develop a …

BACKGROUND AND OBJECTIVE: Capillary electrophoresis (CE) has become an attractive
alternative to SLAB gel analysis for direct and accurate detection of amplified product, and a …

Abstract Background: The Philadelphia chromosome is a cytogenetic change resulting from
a reciprocal translocation of genetic material between ABL genes from chromosome 9 and …

BACKGROUND AND OBJECTIVES: The most common translocation in chronic myeloid
leukemia (CML) t (9; 22)(q34; q22) produces the BCR/ABL fusion gene. We set up and …

The bcr‐abl fusion gene is the hallmark of chronic myeloid leukaemia (CML) and
presumably the cause of its development. Accordingly, long‐term disappearance of the bcr …

Chronic myeloid leukemia (CML) is a clonal myeloproliferative growth of human pluripotent
stem cells which is estimated to occur at a rate of 1/100000 populations every year …

Methods of minimal residual disease (MRD) detection in chronic myelogenous leukemia
(CML) include chromosome analysis, reverse transcriptase polymerase chain reaction (RT …

A novel variant of the chimeric BCR-ABL mRNA transcript was detected in a patient with
Philadelphia chromosome-negative (Ph-) chronic myelogenous leukemia (CML) by …