The roles of macrophages and microglia in multiple sclerosis and experimental autoimmune encephalomyelitis

F Chu, M Shi, C Zheng, D Shen, J Zhu, X Zheng… - Journal of …, 2018 - Elsevier
Multiple sclerosis (MS) is an autoimmune and neurodegenerative disorder characterized by
chronic inflammation, demyelination, as well as axonal and neuronal loss in the central …

Macrophages: a double-edged sword in experimental autoimmune encephalomyelitis

Z Jiang, JX Jiang, GX Zhang - Immunology letters, 2014 - Elsevier
Multiple sclerosis (MS) is a debilitating neurological disorder of the central nervous system
(CNS), characterized by activation and infiltration of leukocytes and dendritic cells into the …

Microglia in central nervous system inflammation and multiple sclerosis pathology

S Voet, M Prinz, G van Loo - Trends in molecular medicine, 2019 - cell.com
Microglia are the resident macrophages of the central nervous system (CNS). They have
important physiological functions in maintaining tissue homeostasis but also contribute to …

In acute experimental autoimmune encephalomyelitis, infiltrating macrophages are immune activated, whereas microglia remain immune suppressed

ID Vainchtein, J Vinet, N Brouwer, S Brendecke… - Glia, 2014 - Wiley Online Library
Multiple sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous
system (CNS) characterized by loss of myelin accompanied by infiltration of T‐lymphocytes …

Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis

EN Benveniste - Journal of molecular medicine, 1997 - Springer
One of the characteristic features of microglia is their rapid activation in response to injury,
inflammation, neurodegeneration, infection, and brain tumors. This review focuses on the …

Differential roles of microglia and monocytes in the inflamed central nervous system

R Yamasaki, H Lu, O Butovsky, N Ohno… - Journal of Experimental …, 2014 - rupress.org
In the human disorder multiple sclerosis (MS) and in the model experimental autoimmune
encephalomyelitis (EAE), macrophages predominate in demyelinated areas and their …

Brain microglia and blood-derived macrophages: molecular profiles and functional roles in multiple sclerosis and animal models of autoimmune demyelinating …

G Raivich, R Banati - Brain Research Reviews, 2004 - Elsevier
Microglia and macrophages, one a brain-resident, the other a mostly hematogenous cell
type, represent two related cell types involved in the brain pathology in multiple sclerosis …

The benefits and detriments of macrophages/microglia in models of multiple sclerosis

KS Rawji, VW Yong - Journal of Immunology Research, 2013 - Wiley Online Library
The central nervous system (CNS) is immune privileged with access to leukocytes being
limited. In several neurological diseases, however, infiltration of immune cells from the …

Microglial cell activation and proliferation precedes the onset of CNS autoimmunity

ED Ponomarev, LP Shriver, K Maresz… - Journal of …, 2005 - Wiley Online Library
Microglial cells are central nervous system (CNS) resident cells that are thought to become
activated and contribute to the inflammation that occurs in the human autoimmune disease …

The role of microglia in multiple sclerosis

C Luo, C Jian, Y Liao, Q Huang, Y Wu… - Neuropsychiatric …, 2017 - Taylor & Francis
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS).
Microglia are the resident innate immune cells in the CNS; they play an important role in the …