iPSC-BASED IMMUNOTHERAPY DIFFERENTIATION PLATFORM ENABLES FEEDER-FREE EXPANSION OF NK CELLS TO CLINICAL SCALE
D Terheyden-Keighley, B Hiller, A Gamerschlag… - Cytotherapy, 2024 - Elsevier
Background & Aim Human induced pluripotent stem cells (iPSCs) are emerging as a potent
starting material for allogeneic cell therapies. As a prerequisite, we have established a GMP …
starting material for allogeneic cell therapies. As a prerequisite, we have established a GMP …
[HTML][HTML] Fit-for-all iPSC-derived cell therapies and their evaluation in humanized mice with NK cell immunity
C Flahou, T Morishima, H Takizawa… - Frontiers in …, 2021 - frontiersin.org
Human induced pluripotent stem cells (iPSCs) can be limitlessly expanded and
differentiated into almost all cell types. Moreover, they are amenable to gene manipulation …
differentiated into almost all cell types. Moreover, they are amenable to gene manipulation …
A Scalable, Off-the-Shelf, and Cost-Effective NK Cell Manufacturing Platform for Developing NK Cell-Based Immunotherapy
Y Yan, L Jiang, Z Zhu, Z Zhu, M Wei, Y Liang, L Shu… - Blood, 2023 - Elsevier
Natural killer (NK) cells are innate lymphocytes that play a key role in the control of infection
and malignancy. NK cells are potent killers of target cells and act in an MHC-independent …
and malignancy. NK cells are potent killers of target cells and act in an MHC-independent …
[HTML][HTML] Induced pluripotent stem cell (iPSC)–derived lymphocytes for adoptive cell immunotherapy: recent advances and challenges
A Nianias, M Themeli - Current hematologic malignancy reports, 2019 - Springer
Abstract Purpose of Review In the rapidly developing field of adoptive cell immunotherapy,
there is urgent need for discoveries that would improve outcomes, extend the applicability …
there is urgent need for discoveries that would improve outcomes, extend the applicability …
[HTML][HTML] Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy
KV Woan, H Kim, R Bjordahl, ZB Davis, S Gaidarova… - Cell Stem Cell, 2021 - cell.com
Select subsets of immune effector cells have the greatest propensity to mediate antitumor
responses. However, procuring these subsets is challenging, and cell-based …
responses. However, procuring these subsets is challenging, and cell-based …
[HTML][HTML] Immune Cell Generation from Human-Induced Pluripotent Stem Cells: Current Status and Challenges
YY Xiong, YW Zheng - 2023 - intechopen.com
The immune system plays a crucial role in recognizing and eliminating foreign antigens,
working in conjunction with other bodily systems to maintain the stability and physiological …
working in conjunction with other bodily systems to maintain the stability and physiological …
[HTML][HTML] Development of innate immune cells from human pluripotent stem cells
Mouse and human pluripotent stem cells have been widely used to study the development
of the hematopoietic and immune systems. Although not all cells can be derived with the …
of the hematopoietic and immune systems. Although not all cells can be derived with the …
[HTML][HTML] Engineering induced pluripotent stem cells for cancer immunotherapy
Simple Summary Induced pluripotent stem cells (iPSCs) that can be genetically engineered
and differentiated into different types of immune cells, providing an unlimited resource for …
and differentiated into different types of immune cells, providing an unlimited resource for …
Induced pluripotent stem cells–derived hematopoietic progenitors for cellular immunotherapies
Cellular therapies combined with genetic engineering technologies have emerged as
increasingly powerful tools for immunotherapies of cancers and viral infections including HIV …
increasingly powerful tools for immunotherapies of cancers and viral infections including HIV …
[HTML][HTML] iPSC-derived natural killer cells for cancer immunotherapy
P Karagiannis, SI Kim - Molecules and cells, 2021 - Elsevier
The discovery of human pluripotent stem cells (PSCs) at the turn of the century opened the
door to a new generation of regenerative medicine research. Among PSCs, the donors …
door to a new generation of regenerative medicine research. Among PSCs, the donors …