The retinoblastoma tumor suppressor gene, Rb, was the first tumor suppressor identified
and plays a fundamental role in regulation of progression through the cell cycle. This review …

Since its discovery, the retinoblastoma (RB) tumour-suppressor protein has been a focal
point of cancer research. Accumulating evidence indicates a complex role for RB in cell …

Studies aimed at examining the precise function (s) of the retinoblastoma tumor suppressor
protein, RB, have been hindered by the rapid phosphorylation and inactivation of ectopically …

For a gene whose existence was first postulated in 1971, was cloned in 1986 and whose
functions have been extensively characterized ever since, you might be inclined to think …

The retinoblastoma tumor-suppressor gene (Rb1) is centrally important in cancer research.
Mutational inactivation of Rb1 causes the pediatric cancer retinoblastoma, while …

The retinoblastoma (RB) tumour suppressor gene is functionally inactivated in a broad
range of paediatric and adult cancers, and a plethora of cellular functions and partners have …

The retinoblastoma tumour suppressor protein (Rb) has come a long way since its initial
discovery in 1986. Encoded by the first candidate tumour suppressor gene it has emerged a …

The identification of the retinoblastoma gene (rb) has sparked intense inves tigation of tumor
suppressor genes. These genes, like oncogenes, can encode transcriptional regulators …

Early studies of the retinoblastoma gene (RB) have uncovered its critical role as a regulator
of the G 1/S cell cycle phase progression. Surprisingly, genetic approaches in mammals and …

The retinoblastoma tumor suppressor (RB) is functionally inactivated at high frequency in
human cancers. Based on the role of RB as a negative regulator of cell cycle this event …