Clinical-Grade Generation of Active NK Cells from Cord Blood Hematopoietic Progenitor Cells for Immunotherapy Using a Closed-System Culture Process

J Spanholtz, F Preijers, M Tordoir, C Trilsbeek… - PloS one, 2011 - journals.plos.org
Natural killer (NK) cell-based adoptive immunotherapy is a promising treatment approach for
many cancers. However, development of protocols that provide large numbers of functional …

High log-scale expansion of functional human natural killer cells from umbilical cord blood CD34-positive cells for adoptive cancer immunotherapy

J Spanholtz, M Tordoir, D Eissens, F Preijers… - PloS one, 2010 - journals.plos.org
Immunotherapy based on natural killer (NK) cell infusions is a potential adjuvant treatment
for many cancers. Such therapeutic application in humans requires large numbers of …

Natural killer cells generated from cord blood hematopoietic progenitor cells efficiently target bone marrow-residing human leukemia cells in NOD/SCID/IL2Rgnull …

J Cany, AB van der Waart, M Tordoir, GM Franssen… - PloS one, 2013 - journals.plos.org
Natural killer (NK) cell-based adoptive immunotherapy is an attractive adjuvant treatment
option for patients with acute myeloid leukemia. Recently, we reported a clinical-grade …

Antigen presenting cell-mediated expansion of human umbilical cord blood yields log-scale expansion of natural killer cells with anti-myeloma activity

N Shah, B Martin-Antonio, H Yang, S Ku, DA Lee… - PloS one, 2013 - journals.plos.org
Natural killer (NK) cells are important mediators of anti-tumor immunity and are active
against several hematologic malignancies, including multiple myeloma (MM). Umbilical cord …

Clinical-grade, large-scale, feeder-free expansion of highly active human natural killer cells for adoptive immunotherapy using an automated bioreactor

T Sutlu, B Stellan, M Gilljam, HC Quezada, H Nahi… - …, 2010 - Taylor & Francis
Background aims. Natural killer (NK) cell-based adoptive immunotherapy is a promising
approach for the treatment of cancer. Ex vivo expansion and activation of NK cells under …

[HTML][HTML] Generating natural killer cells for adoptive transfer: expanding horizons

S Kundu, M Gurney, M O'Dwyer - Cytotherapy, 2021 - Elsevier
Natural killer (NK) cells are unique innate lymphoid cells that have therapeutic potential in
adoptive cell transfer-based cancer immunotherapy that has been established across a …

[图书][B] An improved method to produce clinical-scale natural killer cells from human pluripotent stem cells

H Zhu, DS Kaufman - 2019 - Springer
Human natural killer (NK) cell-based adoptive anticancer immunotherapy has gained
intense interest with many clinical trials actively recruiting patients to treat a variety of both …

Cord blood-derived natural killer cell exploitation in immunotherapy protocols: more than a promise?

L Damele, GM Spaggiari, M Parodi, MC Mingari… - Cancers, 2022 - mdpi.com
Simple Summary NK cell anti-tumor activity against hematological malignancies is well-
established and many studies support their role in the control of solid tumor growth and …

iPSC-derived natural killer cell therapies-expansion and targeting

BH Goldenson, P Hor, DS Kaufman - Frontiers in immunology, 2022 - frontiersin.org
Treatment of cancer with allogeneic natural killer (NK) cell therapies has seen rapid
development, especially use against hematologic malignancies. Clinical trials of NK cell …

GMP-Compliant, Large-Scale Expanded Allogeneic Natural Killer Cells Have Potent Cytolytic Activity against Cancer Cells In Vitro and In Vivo

O Lim, Y Lee, H Chung, JH Her, SM Kang, M Jung… - PLoS one, 2013 - journals.plos.org
Ex vivo-expanded, allogeneic natural killer (NK) cells can be used for the treatment of
various types of cancer. In allogeneic NK cell therapy, NK cells from healthy donors must be …