Rationale: Chronic obstructive pulmonary disease (COPD) is a major cause of death
worldwide. No therapy stopping progress of the disease is available. Objectives: To …

Objective Soluble guanylate cyclase (sGC) is a key enzyme of the nitric oxide–cyclic
guanosine 3′, 5′-monophosphate (NO–cGMP) signaling pathway, and its …

Rationale: Soluble guanylyl cyclase (sGC), a cyclic guanosine 5′-monophosphate–
generating enzyme, regulates smooth muscle tone and exerts antiinflammatory effects in …

Inspiratory resistive breathing (RB), encountered in obstructive lung diseases, induces lung
injury. The soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP) …

Background—Nitric oxide (NO) activates soluble guanylate cyclase (sGC), a heterodimer
composed of α-and β-subunits, to produce cGMP. NO reduces pulmonary vascular …

Soluble guanylyl cyclase (sGC) is a cGMP-generating enzyme implicated in the control of
smooth muscle tone that also regulates platelet aggregation. Moreover, sGC activation has …

Rationale Chronic obstructive pulmonary disease (COPD) is a widespread disease, with no
curative therapies available. Recent findings suggest a key role of NO and sGC-cGMP …

Soluble guanylyl cyclase (sGC) is an enzyme highly expressed in the lung that generates
cGMP contributing to airway smooth muscle relaxation. To determine whether the …

The nitric oxide (NO)-cGMP signal transduction pathway plays an important role in the
regulation of pulmonary vascular tone and resistance in pulmonary hypertension. A number …

High tidal volume (HVT) ventilation causes pulmonary endothelial barrier dysfunction. HVT
ventilation also increases lung nitric oxide (NO) and cGMP. NO contributes to HVT lung …