Intracellular transport by active diffusion

CP Brangwynne, GH Koenderink, FC MacKintosh… - Trends in cell …, 2009 - cell.com
All substances exhibit constant random motion at the microscopic scale. This is a direct
consequence of thermal agitation, and leads to diffusion of molecules and small particles in …

Diffusion and directed motion in cellular transport

A Caspi, R Granek, M Elbaum - Physical Review E, 2002 - APS
We study the motion of a probe driven by microtubule-associated motors within a living
eukaryotic cell. The measured mean square displacement,< x (t) 2> of engulfed 2 and 3 μ m …

Enhanced diffusion in active intracellular transport

A Caspi, R Granek, M Elbaum - Physical review letters, 2000 - APS
We show that within a living eukaryotic cell, mean square displacement of an engulfed
microsphere shows enhanced diffusion scaling as t 3/2 at short times, with a clear crossover …

Getting around the cell: physical transport in the intracellular world

SS Mogre, AI Brown, EF Koslover - Physical Biology, 2020 - iopscience.iop.org
Eukaryotic cells face the challenging task of transporting a variety of particles through the
complex intracellular milieu in order to deliver, distribute, and mix the many components that …

Cytoplasmic diffusion: molecular motors mix it up

CP Brangwynne, GH Koenderink… - The Journal of cell …, 2008 - rupress.org
Random motion within the cytoplasm gives rise to molecular diffusion; this motion is
essential to many biological processes. However, in addition to thermal Brownian motion …

Temporal analysis of active and passive transport in living cells

D Arcizet, B Meier, E Sackmann, JO Rädler… - Physical review letters, 2008 - APS
The cellular cytoskeleton is a fascinating active network, in which Brownian motion is
intercepted by distinct phases of active transport. We present a time-resolved statistical …

Anomalous transport in the crowded world of biological cells

F Höfling, T Franosch - Reports on Progress in Physics, 2013 - iopscience.iop.org
A ubiquitous observation in cell biology is that the diffusive motion of macromolecules and
organelles is anomalous, and a description simply based on the conventional diffusion …

Weak ergodicity breaking of receptor motion in living cells stemming from random diffusivity

C Manzo, JA Torreno-Pina, P Massignan… - Physical Review X, 2015 - APS
Molecular transport in living systems regulates numerous processes underlying biological
function. Although many cellular components exhibit anomalous diffusion, only recently has …

Non-specific interactions govern cytosolic diffusion of nanosized objects in mammalian cells

F Etoc, E Balloul, C Vicario, D Normanno, D Liße… - Nature materials, 2018 - nature.com
The diffusivity of macromolecules in the cytoplasm of eukaryotic cells varies over orders of
magnitude and dictates the kinetics of cellular processes. However, a general description …

Heterogeneities shape passive intracellular transport

P Witzel, M Götz, Y Lanoiselée, T Franosch… - Biophysical journal, 2019 - cell.com
A living cell's interior is one of the most complex and intrinsically dynamic systems, providing
an elaborate interplay between cytosolic crowding and ATP-driven motion that controls …