The heterogeneity of cellular states in cancer has been linked to drug resistance, cancer
progression and the presence of cancer cells with properties of normal tissue stem cells …

The canonical Wnt cascade has emerged as a critical regulator of stem cells. In many
tissues, activation of Wnt signalling has also been associated with cancer. This has raised …

Disseminated cancer cells from primary tumours can seed in distal tissues, but may take
several years to form overt metastases, a phenomenon that is termed tumour dormancy …

Metastatic growth in distant organs is the major cause of cancer mortality. The development
of metastasis is a multistage process with several rate-limiting steps. Although dissemination …

Shutting down Wnt signal–activated cancer | Nature Genetics Skip to main content Thank you
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Cancer genome sequencing studies indicate that a single breast cancer typically harbours
multiple genetically distinct subclones,,,. As carcinogenesis involves a breakdown in the cell …

Despite the presence of mutations in APC or β-catenin, which are believed to activate the
Wnt signalling cascade constitutively, most colorectal cancers show cellular heterogeneity …

Wnt–β-catenin signalling plays a pivotal role in the homeostasis of the intestinal epithelium
by promoting stem cell renewal,. In the small intestine, epithelial Paneth cells secrete Wnt …

Cancer-associated systemic inflammation is strongly linked to poor disease outcome in
patients with cancer,. For most human epithelial tumour types, high systemic neutrophil-to …

Continuous turnover of epithelia is ensured by the extensive self-renewal capacity of tissue-
specific stem cells. Similarly, epithelial tumour maintenance relies on cancer stem cells …