A new metabolic oxidation pathway of capsaicin (N-[(4-hydroxy-3-methoxyphenyl)-methyl]-8-
methyl-(E)-6-nonenamide), a major pungent and pharmacologically active principle of hot …

Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a primary pungent and irritating principle
present in chilies and red peppers which are widely used as spices. Because of its selective …

The interaction of capsaicin with microsomal drug-metabolizing systems was assessed to
determine the role that bioactivation of capsaicin may play in the induction of hepatotoxicity …

Gastrointestinal absorption of capsaicin and dihydrocapsaicin was studied in rats in vivo and
in situ. Rapid absorption of capsaicin or dihydrocapsaicin from stomach and small intestine …

The metabolism in rats of dihydrocapsaicin, a pungent principle of hot pepper, was
investigated in vivo and in vitro by thin-layer chromatography, high-performance liquid …

Capsaicinoids are botanical irritants present in chili peppers. Chili pepper extracts and
capsaicinoids are common dietary constituents and important pharmaceutical agents. Use of …

Background The homovanillic acid derivative, capsaicin (8-methyl-N-vanillyl-6-nonenamide,
Fig. 1), is the principal pungent component of hot peppers. These fruits comprise the plant …

This study characterized electrophilic and radical products derived from the metabolism of
capsaicin by cytochrome P450 and peroxidase enzymes. Multiple glutathione and β …

Publisher Summary This chapter discusses the metabolism of capsaicin—a pungent
principle of red pepper—with rat liver homogenates in vitro. Capsaicin is the main pungent …

Previous studies on the metabolism of capsaicinoids, natural products isolated from chili
peppers, demonstrated the production of unique macrocyclic, alkyl dehydrogenated, ω-, and …