Translating data from animal models into methods for preventing human autoimmune diabetes mellitus: caveat emptor and primum non nocere
DL Greiner, AA Rossini, JP Mordes - Clinical Immunology, 2001 - Elsevier
Type 1 diabetes in humans is a serious autoimmune disorder of children that is still poorly
understood, unpreventable, and irreversible. Study of its animal models, notably the NOD …
understood, unpreventable, and irreversible. Study of its animal models, notably the NOD …
Are insights gained from NOD mice sufficient to guide clinical translation? Another inconvenient truth
BO Roep - Annals of the New York Academy of Sciences, 2007 - Wiley Online Library
Despite decades of research using various animal models for type 1 diabetes, we are still
struggling to define the initiating autoantigens, the precise mechanisms of β cell destruction …
struggling to define the initiating autoantigens, the precise mechanisms of β cell destruction …
The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes
JA Pearson, FS Wong, L Wen - Journal of autoimmunity, 2016 - Elsevier
Abstract Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic
infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing …
infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing …
An update on the use of NOD mice to study autoimmune (Type 1) diabetes
RJ Chaparro, TP DiLorenzo - Expert review of clinical immunology, 2010 - Taylor & Francis
The widely used nonobese diabetic (NOD) mouse model of autoimmune (Type 1) diabetes
mellitus shares multiple characteristics with the human disease, and studies employing this …
mellitus shares multiple characteristics with the human disease, and studies employing this …
Use of nonobese diabetic mice to understand human type 1 diabetes
TC Thayer, SB Wilson… - … and Metabolism Clinics, 2010 - endo.theclinics.com
The use of animal models to study diseases is fundamental to the advancement of the
understanding of basic biologic mechanisms and disease-specific dysfunctions and to the …
understanding of basic biologic mechanisms and disease-specific dysfunctions and to the …
Advances in our understanding of the pathophysiology of Type 1 diabetes: lessons from the NOD mouse
A Jayasimhan, KP Mansour, RM Slattery - Clinical science, 2014 - portlandpress.com
T1D (Type 1 diabetes) is an autoimmune disease caused by the immune-mediated
destruction of pancreatic β-cells. Studies in T1D patients have been limited by the …
destruction of pancreatic β-cells. Studies in T1D patients have been limited by the …
Dissecting autoimmune diabetes through genetic manipulation of non-obese diabetic mice
Y Yang, P Santamaria - Diabetologia, 2003 - Springer
Type 1 diabetes results from a genetically and immunologically complex autoimmune
process that is specifically directed against the pancreatic beta cells. Non-obese diabetic …
process that is specifically directed against the pancreatic beta cells. Non-obese diabetic …
Comparative pathogenesis of autoimmune diabetes in humans, NOD mice, and canines: has a valuable animal model of type 1 diabetes been overlooked?
AL O'Kell, C Wasserfall, B Catchpole, LJ Davison… - Diabetes, 2017 - Am Diabetes Assoc
Despite decades of research in humans and mouse models of disease, substantial gaps
remain in our understanding of pathogenic mechanisms underlying the development of type …
remain in our understanding of pathogenic mechanisms underlying the development of type …
Remodeling rodent models to mimic human type 1 diabetes
M von Herrath, GT Nepom - European journal of immunology, 2009 - Wiley Online Library
Abstract Type 1 diabetes (T1D) occurs when the immune system attacks the insulin‐
producing beta cells located in the islets of Langerhans within the pancreas. Animal models …
producing beta cells located in the islets of Langerhans within the pancreas. Animal models …
[HTML][HTML] The role of NOD mice in type 1 diabetes research: lessons from the past and recommendations for the future
For more than 35 years, the NOD mouse has been the primary animal model for studying
autoimmune diabetes. During this time, striking similarities to the human disease have been …
autoimmune diabetes. During this time, striking similarities to the human disease have been …