Autoimmune diabetes is a polygenic disease process in man and rodents. To identify and
characterize genes involved in the pathogenesis of diabetes in nonobese diabetic (NOD) …

The nonobese diabetic (NOD) mouse spontaneously develops an autoimmune diabetes that
shares many immunogenetic features with human insulin‐dependent diabetes mellitus …

We have used the public sequencing and annotation of the mouse genome to delimit the
previously resolved type 1 diabetes (T1D) insulin-dependent diabetes (Idd) 18 interval to a …

T cell epitopes represent the molecular code words through which the adaptive immune
system communicates. In the context of a T cell-mediated autoimmune disease such as type …

Despite considerable effort to halt or delay destruction of β-cells in autoimmune type 1
diabetes (T1D), success remains elusive. Over the last decade, we have seen a proliferation …

Human epidemiological studies delineated early exposure to intact dietary protein (eg, most
infant formulas) as an environmental risk factor for the development of IDDM. The Trial to …

Type 1 diabetes is a multigenic autoimmune disease, the genetic basis for which is perhaps
best characterized in the nonobese diabetic (NOD) mouse model. We previously located a …

Autoimmune diabetes in both the human and the nonobese diabetic mouse has elaborate
genetics; in the latter case, the disease is influenced by at least 15–20 loci. We anticipated …

In 1974, the discovery of a mouse and a rat that spontaneously developed hyperglycemia
led to the development of 2 autoimmune diabetes models: nonobese diabetic (NOD) mouse …

Type 1, or autoimmune, diabetes is caused by the T-cell mediated destruction of the insulin-
producing pancreatic beta cells. Non-obese diabetic (NOD) mice spontaneously develop …