SIRT6 belongs to the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases
and has established diverse roles in aging, metabolism and disease. Its function is similar to …

Abstract Sirtuin 6 (SIRT6) is a member of the sirtuin family NAD+-dependent deacetylases
with multiple roles in controlling organism homeostasis, lifespan, and diseases. Due to its …

Cardiovascular disease (CVD) is the leading cause of death worldwide, with aging as the
key independent risk factor. Effective interventions are necessary to delay aging. Sirtuin1 …

As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …

The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …

Aging is a key risk factor for angiogenic dysfunction and cardiovascular diseases, including
heart failure, hypertension, atherosclerosis, diabetes, and stroke. Members of the NAD+ …

Sirtuin (the mammalian homolog of silent information regulation 2 of yeast Saccharomyces
cerevisiae) 1 (SIRT1), a NAD-dependent histone deacetylase, has emerged as a critical …

Aging is characterized by progressive functional deterioration with increased risk of
mortality. It is a complex biological process driven by a multitude of intertwined mechanisms …

Sirtuin 1 (SIRT1), the mammalian ortholog of yeast Sir2p, is a highly conserved NAD+-
dependent protein deacetylase that has emerged as a key cardiometabolic regulator. During …

Sirtuins (SIRTs) are a nicotinic adenine dinucleotide (+)-dependent histone deacetylase that
regulates critical signaling pathways in prokaryotes and eukaryotes. Studies have identified …