Cytosine methylation is a DNA modification generally associated with transcriptional
silencing. Factors that regulate methylation have been linked to human disease, yet how …

Mammalian cellular differen-tiation and development depend on stable, somatically
heritable epigenetic switches. A good example is X chromosome inactivation, the random …

DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …

In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …

Methylation of cytosine within DNA is associated with transcriptional repression and genome
surveillance. In plants and animals, conserved pathways exist to establish and maintain this …

Abstract DNA methylation, through 5-methyl-and 5-hydroxymethylcytosine (5mC and 5hmC),
is considered to be one of the principal interfaces between the genome and our …

Cytosine methylation is an epigenetic mechanism in eukaryotes that is often associated with
stable transcriptional silencing, such as in X-chromosome inactivation and genomic …

Patterns of DNA cytosine methylation are subject to mitotic inheritance in both plants and
vertebrates. Plants use 5-methylcytosine glycosylases and the base excision repair pathway …

Many anecdotal observations exist of a regulatory effect of DNA methylation on gene
expression. However, in general, the underlying mechanisms of this effect are poorly …

DNA methylation patterns are set up early in mammalian development and are then copied
during the division of somatic cells. A long-established model for the maintenance of these …