It is well known that solid hypoxic tumour cells oxidise glucose through glycolysis, and the
end product of this pathway is fermented into lactate which accumulates in the tumour …

Metabolic reprogramming is one of fourteen hallmarks of tumor cells, among which aerobic
glycolysis, often known as the “Warburg effect,” is essential to the fast proliferation and …

Global metabolism of cancers exhibits a peculiar phenotype that is lactate acidosis (high
lactate with acidic pH) in tumor microenvironment. Why tumor microenvironment becomes …

Simple Summary The role of lactate in cancer described by Otto Warburg in 1927 states that
cancer cells uptake high amount of glucose with a marked increase in lactate production …

To sustain their high proliferation rates, most cancer cells rely on glycolytic metabolism, with
production of lactic acid. For many years, lactate was seen as a metabolic waste of glycolytic …

Tumor evolution is influenced by events involving tumor cells and the environment in which
they live, known as the tumor microenvironment (TME). TME is a functional and structural …

Cancer cells are able to rewire their metabolism in order to support and allow rapid
proliferation, continuous growth, and survival in hostile conditions, such as acidosis and …

Lactate, the main product of tumor glycolysis is considered one of the most crucial
metabolites in the tumor microenvironment. The reprogrammed cancer cell metabolism is …

Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain
cell proliferation requirements. Otto Warburg showed that tumor cells uptake high amounts …

Lactate acidosis is often observed in the tumor microenvironment (TME) of solid tumors. This
is because glucose breaks down quickly via glycolysis, causing lactate acidity. Lactate is …