An epigenome-wide view of osteoarthritis in primary tissues
P Kreitmaier, M Suderman, L Southam… - The American Journal of …, 2022 - cell.com
Osteoarthritis is a complex degenerative joint disease. Here, we investigate matched
genotype and methylation profiles of primary chondrocytes from macroscopically intact (low …
genotype and methylation profiles of primary chondrocytes from macroscopically intact (low …
The epigenomic landscape in osteoarthritis
TC Simon, MA Jeffries - Current rheumatology reports, 2017 - Springer
Abstract Purpose of Review Epigenomics has emerged as a key player in our rapidly
evolving understanding of osteoarthritis. Historical studies implicated epigenetic alterations …
evolving understanding of osteoarthritis. Historical studies implicated epigenetic alterations …
[HTML][HTML] Genome-wide DNA methylation profile implicates potential cartilage regeneration at the late stage of knee osteoarthritis
Y Zhang, N Fukui, M Yahata, Y Katsuragawa… - Osteoarthritis and …, 2016 - Elsevier
Objective The aim of this work was to characterize the genome-wide DNA methylation profile
of cartilage from three regions of tibial plateau isolated from patients with primary knee …
of cartilage from three regions of tibial plateau isolated from patients with primary knee …
Epigenetic differences in human cartilage between mild and severe OA
FC Moazedi‐Fuerst, M Hofner, G Gruber… - Journal of …, 2014 - Wiley Online Library
The development of osteoarthritis (OA) depends on genetic and environmental factors,
which influence the biology of the chondrocyte via epigenetic regulation. Changes within the …
which influence the biology of the chondrocyte via epigenetic regulation. Changes within the …
Identification of DNA methylation associated enrichment pathways in adults with non-specific chronic low back pain
Chronic low back pain (cLBP) that cannot be attributable to a specific pathoanatomical
change is associated with high personal and societal costs. Still, the underlying mechanism …
change is associated with high personal and societal costs. Still, the underlying mechanism …
Identification of an epigenetic signature of osteoporosis in blood DNA of postmenopausal women
Osteoporosis is one of the most common age‐related progressive bone diseases in elderly
people. Approximately one in three women and one in five men are predisposed to …
people. Approximately one in three women and one in five men are predisposed to …
DNA methylation signatures of bone metabolism in osteoporosis and osteoarthritis aging-related diseases: an updated review
VV Visconti, I Cariati, S Fittipaldi, R Iundusi… - International Journal of …, 2021 - mdpi.com
DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in
regulating gene expression. The epigenetic component is strongly involved in aging-bone …
regulating gene expression. The epigenetic component is strongly involved in aging-bone …
Functional genomics in osteoarthritis: past, present, and future
J Steinberg, E Zeggini - Journal of Orthopaedic Research, 2016 - Wiley Online Library
Osteoarthritis (OA) is a common complex disease of high public health burden. OA is
characterized by the degeneration of affected joints leading to pain and reduced mobility …
characterized by the degeneration of affected joints leading to pain and reduced mobility …
Genome‐wide mapping of DNA hydroxymethylation in osteoarthritic chondrocytes
SEB Taylor, YH Li, WH Wong… - Arthritis & …, 2015 - Wiley Online Library
Objective To examine the genome‐wide distribution of hydroxymethylated cytosine (5hmC)
in osteoarthritic (OA) and normal chondrocytes in order to investigate the effect on OA …
in osteoarthritic (OA) and normal chondrocytes in order to investigate the effect on OA …
Epigenome-wide association study of rheumatoid arthritis identifies differentially methylated loci in B cells
A Julià, D Absher, M López-Lasanta… - Human molecular …, 2017 - academic.oup.com
Epigenetic regulation of immune cell types could be critical for the development and
maintenance of autoimmune diseases like rheumatoid arthritis (RA). B cells are highly …
maintenance of autoimmune diseases like rheumatoid arthritis (RA). B cells are highly …