Objective To identify methylation quantitative trait loci (mQTL s) correlating with osteoarthritis
(OA) risk alleles and to undertake mechanistic characterization as a means of target gene …

Objective Osteoarthritis (OA) is polygenic, with more than 90 risk loci currently mapped,
including at the single‐nucleotide polymorphism rs6516886. Previous analysis of OA …

Objectives Epigenetics can influence disease susceptibility and severity. While DNA
methylation of individual genes has been explored in autoimmunity, no unbiased systematic …

Background Ankylosing spondylitis (AS) is a chronic rheumatic and autoimmune disease.
Little is known about the potential role of DNA methylation in the pathogenesis of AS. This …

Objectives To elucidate the functional epigenomic landscape of articular cartilage in
osteoarthritis (OA) affected knee and hip joints in relation to gene expression. Methods …

Background Rheumatoid arthritis is a common autoimmune disorder influenced by both
genetic and environmental factors. Epigenome-wide association studies can identify …

Progress in genetic research has delivered important highlights in the last year. One of the
widest impact is the publication of the Encyclopedia of DNA Elements (ENCODE) project …

Objective In gout, autoinflammatory responses to urate crystals promote acute arthritis flares,
but the pathogeneses of tophi, chronic synovitis, and erosion are less well understood …

Background A DNA methylation signature has been characterized that distinguishes
rheumatoid arthritis (RA) fibroblast like synoviocytes (FLS) from osteoarthritis (OA) FLS. The …

Changes to the DNA methylome have been described in patients with rheumatoid arthritis
(RA). In previous work, we reported genome-wide methylation differences in T-lymphocyte …