The overall mortality in patients with sepsis is approximately 30%; this figure increases to
50% or higher in patients with septic shock, and sepsis continues to be seen as a major …

Sepsis is a syndrome which is defined as a dysregulated host response to infection leading
to organ failure. Since it remains one of the leading causes of mortality worldwide, numerous …

Sepsis, a common and potentially fatal systemic illness, is triggered by microbial infection
and often leads to impaired function of the lungs, kidneys or other vital organs. Since the …

Multiple clinical trials of adjunctive therapy for sepsis and septic shock have been conducted
to neutralize bacterial components or to modulate host inflammatory responses to infection …

Introduction: Over the last two decades, many of the mechanisms underlying the
pathophysiology of sepsis have been uncovered, but this has not led to the development of …

Sepsis continues to intrigue and challenge drug developers because of the high unmet
need for this illness. The large market potential for sepsis is counterbalanced by the …

D espite recent improvements in intensive care monitoring, diagnostic techniques, and
therapies, sepsis remains common among the critically ill. Moreover, related mortality rates …

The underlying principles of sepsis therapy have remained unchanged for decades. These
include: prompt institution of antimicrobial agents aimed at the inciting pathogen, source …

Introduction Although the pathophysiology of sepsis has been extensively studied, the
disease remains a common cause of death in the critically ill patient. It thus remains one of …

The outcome of patients with sepsis arises from multiple factors affecting both the host and
the invading microorganisms. Age, presence of underlying disease, source of infection and …