During the past five years, important progress has been made in the identification of genes
and/or chromosomal rearrangements that may have direct relevance for the development of …

Somatic changes in the genome of breast cancer cells include amplifications, deletions and
gene mutations. Several chromosome regions harboring known oncogenes are found …

The great heterogeneity of clinical breast cancer probably reflects heterogeneity of the
mechanisms that are involved in its genesis and in disease progression. Genetic events that …

We review and discuss data on the genetic alterations documented in human breast
carcinomas at the molecular level. These alterations may result in: 1) deletion of genetic …

Molecular genetic analysis of breast cancers indicates that the mechanisms underlying
tumorigenesis are complicated. Many oncogenes and tumour suppressor genes have been …

Perhaps one of the most exciting recent developments in breast cancer research is the
steadily increasing number of small screen detected lesions which are available for study …

THE GENETIC basis of breast cancer has received a great deal of attention in the last 10
years. In that time, much progress has been made in characterising the alterations found in …

Breast cancer (BC), like all cancers is considered to be a genetic disease in the sense that
both germline and somatic mutations may be the cause of tumour initiation and …

Publisher Summary This chapter highlights the genetic studies concerned with human
breast cancer and discusses the background of breast cancer histology and clinical aspects …

Chromosomal and molecular biologic studies of human breast cancer are beginning to
provide insight into the basic biology of this important disease. The current state of …