Knowledge on heritable changes in gene expression that result from epigenetic events is of
increasing relevance in the development of strategies for prevention, early diagnosis and …

Gene function in cancer can be disrupted either through genetic alterations, which directly
mutate or delete genes, or epigenetic alterations, which alter the heritable state of gene …

Epigenetic mechanisms including DNA and histone modifications result in silencing of
genes without changing the coding sequence of the gene. Even though these events are …

Chromatin alterations have been associated with all stages of tumour formation and
progression. The best characterized are epigenetically mediated transcriptional-silencing …

The classical theory of recessive oncogenesis predicted a mutational mechanism for the
inactivation of tumor suppressor (TS) genes. This prediction has been amply confirmed, but …

DNA methylation alterations are now widely recognized as a contributing factor in human
tumorigenesis. A significant number of tumor suppressor genes are transcriptionally …

Patterns of DNA methylation and chromatin structure are profoundly altered in neoplasia
and include genome-wide losses of, and regional gains in, DNA methylation. The recent …

Alterations in epigenetic gene regulation are associated with human disease. Here, we
discuss connections between DNA methylation and histone methylation, providing …

Methods of gene inactivation include genetic events such as mutations or deletions.
Epigenetic changes, heritable traits that are mediated by changes in DNA other than …

Epigenetics, a combination of DNA modifications, chromatin organization, and variations in
its associated proteins, configure a new entity that regulates gene expression throughout …