Epigenetics, a combination of DNA modifications, chromatin organization, and variations in
its associated proteins, configure a new entity that regulates gene expression throughout …

Epigenetic inactivation of genes that are crucial for the control of normal cell growth is a
hallmark of cancer cells. These epigenetic mechanisms include crosstalk between DNA …

A cancer develops when a cell acquires specific growth advantages through the stepwise
accumulation of heritable changes in gene function. Basically, this process is directed by …

The phenotype of the cancerous cell may arise either from genetic alterations that disrupt
gene function through sequence modifications (mutations) or epigenetic events that may …

Aberrant gene silencing in mammalian cells is associated with promoter region methylation,
but the sequence of these two events is not clear. This review will consider the possibility …

DNA methylation is associated with the silencing of gene expression. The predominant
mechanism involves the methylation of DNA and the subsequent recruitment of binding …

The mechanism of DNA hypermethylation-associated tumor suppressor gene silencing in
cancer remains incompletely understood. Here, we show by chromatin immunoprecipitation …

Hypermethylation of CpG islands, an epigenetic event that is not accompanied by changes
in DNA sequence, represents an alternative mechanism to deletions or mutations to …

Epigenetic gene inactivation in transformed cells involves many 'belts of silencing'. One of
the best-known lesions of the malignant cell is the transcriptional repression of tumor …

For decades, chromatin was considered to be an inert structure whose only role was the
compacting and confining of DNA inside the eukaryotic nucleus. However, tremendous …