Since its discovery, the retinoblastoma (RB) tumour-suppressor protein has been a focal
point of cancer research. Accumulating evidence indicates a complex role for RB in cell …

The retinoblastoma (RB) tumour suppressor gene is functionally inactivated in a broad
range of paediatric and adult cancers, and a plethora of cellular functions and partners have …

The identification of the retinoblastoma gene (rb) has sparked intense inves tigation of tumor
suppressor genes. These genes, like oncogenes, can encode transcriptional regulators …

The retinoblastoma tumor suppressor gene, Rb, was the first tumor suppressor identified
and plays a fundamental role in regulation of progression through the cell cycle. This review …

For a gene whose existence was first postulated in 1971, was cloned in 1986 and whose
functions have been extensively characterized ever since, you might be inclined to think …

Puzzling new information indicates an inadequacy in our understanding of the
retinoblastoma protein (RB). RB and the transcription factor E2F appear to be collaborators …

The retinoblastoma tumor-suppressor gene (Rb1) is centrally important in cancer research.
Mutational inactivation of Rb1 causes the pediatric cancer retinoblastoma, while …

Rb was the first tumour suppressor identified through human genetic studies. The most
significant achievement after almost twenty years since its cloning is the revelation that Rb …

Retinoblastoma, the most common primary intraocular cancer of childhood, is a malignancy
arising in the developing retina. Tumor formation usually begins with mutation in both alleles …

The retinoblastoma (RB) gene is the prototype tumor suppressor gene. It encodes a nuclear
protein that acts as a cell cycle control checkpoint at the G1 phase. Deletion or inactivation of …