Organoids are three-dimensional in-vitro-grown cell clusters with near-native microanatomy
that arise from self-organizing mammalian pluripotent or adult stem cells. Although …

Background Because of their differentiation potential, pluripotent stem cells can generate
virtually any cell type and, as such, can be used to model development and disease and …

Adult tissue-derived organoids allow for the expansion and maintenance of primary
epithelial cells in a near-native state. These 3D and self-organizing organotypic cultures …

In vitro cell cultures are crucial research tools for modeling human development and
diseases. Although the conventional monolayer cell cultures have been widely used in the …

Tissue stem cells require unique niche microenvironments. In the presence of specific
combinations of niche factors, mouse and human epithelial tissues from stomach, small …

Adult stem cells from a variety of organs can be expanded long-term in vitro as three-
dimensional organotypic structures termed organoids. These adult stem cell-derived …

INTRODUCTION Stem cell–derived organoids are in vitro tissue and organ mimetics that
have enormous potential as models for human organ development and disease, as …

For many tissues, single resident stem cells grown in vitro under appropriate three-
dimensional conditions can produce outgrowths known as organoids. These tissues …

Adult tissue stem cells can form self-organizing 3D organoids in vitro. Organoids resemble
small units of their organ of origin and have great potential for tissue engineering, as well as …

Abstract Three-dimensional (3D) cultures use the property of some cells to self-organize in
matrices and generate structures that can be programmed to represent an organ or a …