Tyrosine levels regulate the melanogenic response to α‐melanocyte‐stimulating hormone in human melanocytes: implications for pigmentation and proliferation

DJ SCHWAHN, W XU, AB HERRIN… - Pigment Cell …, 2001 - Wiley Online Library
Melanocyte‐stimulating hormone (α‐MSH) increases cytosolic levels of cAMP as well as
tyrosinase activity in murine melanocytes. These activities depend upon the presence of …

α‐MSH and melanogenesis in normal human adult melanocytes

SJ Hedley, DJ Gawkrodger, AP Weetman… - Pigment cell …, 1998 - Wiley Online Library
Normal human skin melanocytes do not pigment consistently to α‐melanocyte stimulating
hormone (α‐MSH) in culture. The aim of this study was to establish media conditions in …

Investigation of the regulation of pigmentation in α‐melanocyte‐stimulating hormone responsive and unresponsive cultured B16 melanoma cells

SE HILL, J BUFFEY, AJ THODY… - Pigment Cell …, 1989 - Wiley Online Library
In vitro melanocyte‐stimulating hormone (MSH) stimulates melanogenesis in some, but not
all, melanocytes and melanoma cells. In an attempt to explain this variation in response to …

Effects of melanocyte-stimulating hormone on tyrosinase expression and melanin synthesis in hair follicular melanocytes of the mouse

SA Burchill, S Ito, AJ Thody - Journal of endocrinology, 1993 - joe.bioscientifica.com
Tyrosinase mRNA, synthesis and activity were measured in the skin during the first 2 weeks
of life of C 3 H-HeA vy mice. Tyrosinase mRNA levels were found to peak on days 3–4 and …

Regulation of mammalian melanogenesis by tyrosinase inhibition

K Kameyama, M Jiménez, J Muller, Y Ishida… - Differentiation, 1989 - Elsevier
Melanocyte stimulating hormone (MSH) specifically induces differentiation of mammalian
melanocytes. To further define the biochemical events elicited by this stimulus, we have …

α-melanocyte stimulating hormone and its analogue nle4dphe7α-MSH affect morphology, tyrosinase activity and melanogenesis in cultured human melanocytes

G Hunt, C Todd, JE Cresswell… - Journal of cell …, 1994 - journals.biologists.com
Although melanocyte stimulating hormone (MSH) peptides are known to stimulate
pigmentation in man, previous reports suggest that human melanocytes are relatively …

Cultured human melanocytes respond to MSH peptides and ACTH

G HUNT, PD DONATIEN, J LUNEC… - Pigment Cell …, 1994 - Wiley Online Library
Although the administration of melanocyte‐stimulating hormone (MSH) peptides results in
skin darkening in man, cultured human melanocytes have been reported to be unresponsive …

D‐tyrosine negatively regulates melanin synthesis by competitively inhibiting tyrosinase activity

J Park, H Jung, K Kim, KM Lim, J Kim… - Pigment cell & …, 2018 - Wiley Online Library
Although L‐tyrosine is well known for its melanogenic effect, the contribution of D‐tyrosine to
melanin synthesis was previously unexplored. Here, we reveal that, unlike L‐tyrosine, D …

Regulation of tyrosinase synthesis and its processing in the hair follicular melanocytes of the mouse during eumelanogenesis and phaeomelanogenesis

SA Burchill, R Virden, AJ Thody - Journal of investigative dermatology, 1989 - Elsevier
Tyrosinase synthesis and its posttranslational processing was compared in hair follicular
melanocytes of C 3 H-HeA vy mice during eumelanogenesis and phaeomelanogenesis …

Melanogenesis in cultured melanocytes can be substantially influenced by L-tyrosine and L-cysteine

NPM Smit, H Van der Meulen, HK Koerten… - Journal of investigative …, 1997 - Elsevier
We investigated the effect of varying concentration of 1-tyrosine and 1-cysteine in culture
medium on melanin production by human skin melanocytes (skin phototype II/III). In addition …