Tumor growth is not determined solely by the tumor cells but is governed by interactions
between tumor cells and host stromal cells, including endothelial cell activation and …

The importance of stromal cells and the factors that they express during cancer initiation and
progression has been highlighted by recent literature. The cellular components of the stroma …

Development of a tumor is a parallel event with the expansion of tumor microenvironment.
Although most of the treatment strategies target only malignant cells, advanced …

Bone marrow mesenchymal stem/stromal cells (BM-MSCs) can infiltrate into tumors and
subsequently evolve into tumor resident MSCs in tumor microenvironment. In this study …

Background: The tumor microenvironment is increasingly recognized as pivotal in tumor
progression. Thus, by completely separating tumor cells from stromal cells it enables a …

The tumor microenvironment plays an essential role in various stages of cancer
development. This environment, composed of the extracellular matrix, fibroblasts …

Mass cytometry imaging is a novel technique that allows sub-cellular resolution
measurements of the abundance of dozen proteins directly in tissues (Giesen et al.,“Highly …

After more than a decade of controversy on the role of stromal cells in the tumor
microenvironment, the emerging data shed light on pro-tumorigenic and potential anti …

In most (if not all) solid tumors, malignant cells are outnumbered by their non-malignant
counterparts, including immune, endothelial and stromal cells. However, while the …

Stromal cells are one of the important components of tumor mieroenvironment, which plays
an oncogenic role in tumorigenesis. Stromai cells and their products can transform adjacent …