The role of tumor stroma in progression to malignancy has become the subject of intense
experimental and clinical interest. The stromal compartment of organs is composed of all the …

Inflammatory signals secreted from the tumor microenvironment are thought to promote
tumor growth and survival. It has been reported that stromal cells in the tumor …

Simple Summary Tumours consist of different cell types and an extracellular matrix, all of
which together form a complex microenvironment. The tumour microenvironment plays a …

Ten years ago, Hanahan and Weinberg delineated six “Hallmarks of cancer” which
summarize several decades of intense cancer research. However, tumor cells do not act in …

Although the stroma within carcinogenic lesions is known to be supportive and responsive to
tumors, new data increasingly show that the stroma also has a more active, oncogenic role …

Malignant transformation of an epithelium occurs within the context of a dynamically
evolving tissue stroma that is composed of multiple cell types surrounded by an extracellular …

Compelling experimental evidence has recently unveiled that the tumor microenvironment
plays a crucial role in tumor progression. Importantly, bone marrow-derived mesenchymal …

The stroma is a major component of tissues. In a homeostatic condition, stroma of healthy
tissues regulates tissue growth, function, and reactivity to external agents by elaborating and …

The basement membrane, immune cells, capillaries, fibroblasts and extracellular matrix
(ECM) constitute the tumour stroma, commonly referred to as the 'reactive stroma'. The …

Simple Summary Cancers have regions of low oxygen concentration where hypoxia-related
signaling pathways are activated. The hypoxic tumor microenvironment has been widely …